(R)-Baclofen, GABAB agonist (ab120325)
Key features and details
- Selective GABAB agonist. Active enantiomer.
- CAS Number: 69308-37-8
- Soluble in water to 25 mM and in 1 eq. NaOH to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
(R)-Baclofen, GABAB agonist -
製品の詳細
Selective GABAB agonist. Active enantiomer. -
生理活性の詳細
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CAS 番号
69308-37-8 -
構造式
製品の特性
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体系名
(R)-4-Amino-3-(4-chlorophenyl)butanoic acid -
分子量
213.66 -
分子式
C10H12ClNO2 -
PubChem 登録番号
44602 -
保存方法
Store at Room Temperature. The product can be stored for up to 12 months. -
溶解性
Soluble in water to 25 mM and in 1 eq. NaOH to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
Clc1ccc(cc1)[C@H](CN)CC(=O)O -
由来
Synthetic
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研究分野
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プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (4)
ab120325 は 4 報の論文で使用されています。
- Booker SA et al. Presynaptic GABAB receptors functionally uncouple somatostatin interneurons from the active hippocampal network. Elife 9:N/A (2020). PubMed: 32073397
- Llamosas N et al. Inactivation of GIRK channels weakens the pre- and postsynaptic inhibitory activity in dorsal raphe neurons. Physiol Rep 5:N/A (2017). PubMed: 28196855
- Beckley JT et al. Medial prefrontal cortex inversely regulates toluene-induced changes in markers of synaptic plasticity of mesolimbic dopamine neurons. J Neurosci 33:804-13 (2013). PubMed: 23303956
- Wang X et al. Effects of the allosteric antagonist 1-(4-chlorophenyl)-3-[3-(6-pyrrolidin-1-ylpyridin-2-yl)phenyl]urea (PSNCBAM-1) on CB1 receptor modulation in the cerebellum. Mol Pharmacol 79:758-67 (2011). PubMed: 21189269