QNZ, NF-kB inhibitor (ab141588)
Key features and details
- Potent, selective NF-kB inhibitor
- CAS Number: 545380-34-5
- Purity: > 98%
- Soluble in DMSO to 50 mM and in ethanol to 25 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
-
製品名
QNZ, NF-kB inhibitor -
製品の詳細
Potent, selective NF-kB inhibitor -
精製度
> 98% -
CAS 番号
545380-34-5 -
構造式
製品の特性
-
体系名
4-N-[2-(4-Phenoxyphenyl)ethyl]-1,2-dihydroquinazoline-4,6-diamine -
分子量
356.40 -
分子式
C22H20N4O -
PubChem 登録番号
35026803 -
保存方法
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 50 mM and in ethanol to 25 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES 線形表記
C1NC2=C(C=C(C=C2)N)C(=N1)NCCC3=CC=C(C=C3)OC4=CC=CC=C4 -
由来
Synthetic
-
研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
-
SDS download
-
Datasheet download
参考文献 (7)
ab141588 は 7 報の論文で使用されています。
- Liu X et al. Mitochondria-Targeted Triphenylphosphonium-Hydroxytyrosol Prevents Lipotoxicity-Induced Endothelial Injury by Enhancing Mitochondrial Function and Redox Balance via Promoting FoxO1 and Nrf2 Nuclear Translocation and Suppressing Inflammation via Inhibiting p38/NF-кB Pathway. Antioxidants (Basel) 12:N/A (2023). PubMed: 36671037
- Peng X et al. Nuclear Factor-Kappa B-induced miRNA-518a-5p represses trophoblast cell migration and invasion by the Nuclear Factor-Kappa B pathway. An Acad Bras Cienc 95:e20220596 (2023). PubMed: 37132750
- Balachandran Y et al. Regulation of TLR10 Expression and Its Role in Chemotaxis of Human Neutrophils. J Innate Immun 14:629-642 (2022). PubMed: 35613551
- Zhu Y et al. Protective role of long noncoding RNA CRNDE in myocardial tissues from injury caused by sepsis through the microRNA-29a/SIRT1 axis. Life Sci 255:117849 (2020). PubMed: 32473249
- Xi XJ et al. Extracellular vesicles enhance oxidative stress through P38/NF-kB pathway in ketamine-induced ulcerative cystitis. J Cell Mol Med 24:7609-7624 (2020). PubMed: 32441055
- Liu S & Li W Prazosin blocks apoptosis of endothelial progenitor cells through downregulating the Akt/NF-?B signaling pathway in a rat cerebral infarction model. Exp Ther Med 20:2577-2584 (2020). PubMed: 32765751
- Qing P & Liu Y Inhibitory role of long non-coding RNA OIP5-AS1 in rheumatoid arthritis progression through the microRNA-448-paraoxonase 1-toll-like receptor 3-nuclear factor ?B axis. Exp Physiol 105:1708-1719 (2020). PubMed: 32770578