Purmorphamine, Smoothened receptor agonist (ab120933)
Key features and details
- Smoothened receptor agonist
- CAS Number: 483367-10-8
- Purity: > 98%
- Soluble in DMSO to 10 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
Purmorphamine, Smoothened receptor agonist -
製品の詳細
Smoothened receptor agonist -
生理活性の詳細
Smoothened (Smo) receptor agonist (EC50 ~ 1 μM). Induces osteogenesis in mouse mesenchymal progenitor cells . When combined with BMP-4, can transdifferentiate pre-adipocytes and myoblasts into osteoblasts. Induces differentiation of multipotent mesenchymal progenitor cells into osteoblasts.
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精製度
> 98% -
CAS 番号
483367-10-8 -
構造式
製品の特性
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体系名
9-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine -
分子量
520.63 -
分子式
C31H32N6O2 -
保存方法
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 10 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
O1CCN(CC1)c1ccc(cc1)Nc1nc(Oc2cccc3ccccc23)nc2c1ncn2C1CCCCC1 -
由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (6)
ab120933 は 6 報の論文で使用されています。
- Chiuso F et al. Ubiquitylation of BBSome is required for ciliary assembly and signaling. EMBO Rep 24:e55571 (2023). PubMed: 36744302
- Malave L et al. Dopaminergic co-transmission with sonic hedgehog inhibits abnormal involuntary movements in models of Parkinson's disease and L-Dopa induced dyskinesia. Commun Biol 4:1071 (2021). PubMed: 34552196
- Senatore E et al. The TBC1D31/praja2 complex controls primary ciliogenesis through PKA-directed OFD1 ubiquitylation. EMBO J 40:e106503 (2021). PubMed: 33934390
- Park SR et al. Sonic Hedgehog, a Novel Endogenous Damage Signal, Activates Multiple Beneficial Functions of Human Endometrial Stem Cells. Mol Ther 28:452-465 (2020). PubMed: 31866117
- Kozielewicz P et al. Structural insight into small molecule action on Frizzleds. Nat Commun 11:414 (2020). PubMed: 31964872
- Cho A et al. An Endogenous Anti-aging Factor, Sonic Hedgehog, Suppresses Endometrial Stem Cell Aging through SERPINB2. Mol Ther 27:1286-1298 (2019). PubMed: 31080015