Anti-PSPH 抗体 (ab96414)
Key features and details
- Rabbit polyclonal to PSPH
- Suitable for: WB, ICC/IF
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-PSPH antibody
PSPH 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to PSPH -
由来種
Rabbit -
アプリケーション
適用あり: WB, ICC/IFmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse, Rat, Cow -
免疫原
Recombinant fragment corresponding to Human PSPH aa 1-195 (N terminal).
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ポジティブ・コントロール
- 293T, A431, H1299, HeLa, HepG2, MOLT4, Raji cell lysates
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine) -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab96414の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
1/500 - 1/3000. Predicted molecular weight: 25 kDa.
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ICC/IF |
1/100 - 1/200.
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特記事項 |
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WB
1/500 - 1/3000. Predicted molecular weight: 25 kDa. |
ICC/IF
1/100 - 1/200. |
ターゲット情報
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機能
Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates. -
パスウェイ
Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3. -
関連疾患
Defects in PSPH are the cause of phosphoserine phosphatase deficiency (PSPHD)[MIM:614023]. A disorder that results in pre- and postnatal growth retardation, moderate psychomotor retardation and facial features suggestive of Williams syndrome. -
配列類似性
Belongs to the SerB family. - Information by UniProt
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参照データベース
- Entrez Gene: 533630 Cow
- Entrez Gene: 5723 Human
- Entrez Gene: 100678 Mouse
- Entrez Gene: 304429 Rat
- Omim: 172480 Human
- SwissProt: Q2KHU0 Cow
- SwissProt: P78330 Human
- SwissProt: Q99LS3 Mouse
see all -
別名
- EC 3.1.3.3 antibody
- L 3 phosphoserine phosphatase antibody
- L-3-phosphoserine phosphatase antibody
see all
画像
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (3)
ab96414 は 3 報の論文で使用されています。
- Tajan M et al. Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy. Nat Commun 12:366 (2021). PubMed: 33446657
- Hennequart M et al. The impact of physiological metabolite levels on serine uptake, synthesis and utilization in cancer cells. Nat Commun 12:6176 (2021). PubMed: 34702840
- Sen N et al. EWS-FLI1 reprograms the metabolism of Ewing sarcoma cells via positive regulation of glutamine import and serine-glycine biosynthesis. Mol Carcinog 57:1342-1357 (2018). PubMed: 29873416