Psalmotoxin-1, ASIC1a blocker (ab120483)
Key features and details
- Potent, selective ASIC1a blocker
- Soluble in water
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
Psalmotoxin-1, ASIC1a blocker -
製品の詳細
Potent, selective ASIC1a blocker -
別名
- PcTx1
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生理活性の詳細
Potent, selective acid sensing (proton gated) ion channel 1a (ASIC1a) blocker. Inhibits cation currents mediated by ASICs (IC50 = 36 pM). Displays highly potent analgesic properties against neuropathic pain.
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構造式
製品の特性
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分子量
4689.41 -
分子式
C200H312N62O57S6 -
配列
EDCIPKWKGCVNRHGDCCEGLECWKRRRSFEVCVPKTPKT (Modifications: Disulfide bonds: 3-18, 10-23, 17-33) -
PubChem 登録番号
90489000 -
保存方法
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in water -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (5)
ab120483 は 5 報の論文で使用されています。
- Chen X et al. Involvement of acid-sensing ion channel 1a in gastric carcinoma cell migration and invasion. Acta Biochim Biophys Sin (Shanghai) 50:440-446 (2018). PubMed: 29584803
- Jin C et al. Over-expression of ASIC1a promotes proliferation via activation of the ß-catenin/LEF-TCF axis and is associated with disease outcome in liver cancer. Oncotarget 8:25977-25988 (2017). PubMed: 27462920
- Dai B et al. ASIC1a Promotes Acid-Induced Autophagy in Rat Articular Chondrocytes through the AMPK/FoxO3a Pathway. Int J Mol Sci 18:N/A (2017). Inhibition Assay ; Rat . PubMed: 29019932
- Zhang J et al. Augmentation of poly(ADP-ribose) polymerase-dependent neuronal cell death by acidosis. J Cereb Blood Flow Metab N/A:N/A (2016). PubMed: 27381826
- Li T et al. A Method for Activation of Endogenous Acid-sensing Ion Channel 1a (ASIC1a) in the Nervous System with High Spatial and Temporal Precision. J Biol Chem 289:15441-15448 (2014). PubMed: 24727474