Anti-ProDynorphin 抗体 (ab10280)
Key features and details
- Guinea pig polyclonal to ProDynorphin
- Suitable for: IHC-Fr
- Reacts with: Rat
- Isotype: IgG
製品の概要
-
製品名
Anti-ProDynorphin antibody
ProDynorphin 一次抗体 製品一覧 -
製品の詳細
Guinea pig polyclonal to ProDynorphin -
由来種
Guinea pig -
アプリケーション
適用あり: IHC-Frmore details -
種交差性
交差種: Rat -
免疫原
Synthetic peptide corresponding to Rat ProDynorphin aa 200 to the C-terminus.
Database link: P06300 -
特記事項
The protein encoded by this gene is a preproprotein that is proteolytically processed to form the secreted opioid peptides beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and leumorphin. These peptides are ligands for the kappa-type of opioid receptor. Dynorphin is involved in modulating responses to several psychoactive substances, including cocaine.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
-
製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
Preservative: 0.05% Sodium azide
Constituent: PBS -
Concentration information loading... -
精製度
Protein A purified -
一次抗体 備考
The protein encoded by this gene is a preproprotein that is proteolytically processed to form the secreted opioid peptides beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and leumorphin. These peptides are ligands for the kappa-type of opioid receptor. Dynorphin is involved in modulating responses to several psychoactive substances, including cocaine. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
-
Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab10280の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| IHC-Fr |
1/500.
|
| 特記事項 |
|---|
|
IHC-Fr
1/500. |
ターゲット情報
-
機能
Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin.
Leumorphin has a typical opiod activity and may have anti-apoptotic effect. -
関連疾患
Defects in PDYN are the cause of spinocerebellar ataxia type 23 (SCA23) [MIM:610245]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA23 is an adult-onset autosomal dominant form characterized by slowly progressive gait and limb ataxia, with variable additional features, including peripheral neuropathy and dysarthria. -
配列類似性
Belongs to the opioid neuropeptide precursor family. -
翻訳後修飾
The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing. -
細胞内局在
Secreted. - Information by UniProt
-
参照データベース
- Entrez Gene: 29190 Rat
- SwissProt: P06300 Rat
- Unigene: 44471 Rat
-
別名
- ADCA antibody
- Alpha neoendorphin antibody
- Beta neoendorphin antibody
see all
画像
-
Immunohistochemistry (Frozen sections) - Anti-ProDynorphin antibody (ab10280)ab10280, at a dilution of 1/500, staining ProDynorphin in rat supraoptic nucleus region by Immunohistochemistry (PFA perfusion fixed frozen sections).
データシートおよび資料
-
Datasheet download
参考文献 (1)
ab10280 は 1 報の論文で使用されています。
- Bröhl D et al. A transcriptional network coordinately determines transmitter and peptidergic fate in the dorsal spinal cord. Dev Biol 322:381-93 (2008). IHC-Fr ; Mouse . PubMed: 18721803
