AB99817

Mouse Anti-Human IgG4 pFc’ [HP6023] (HRP)

Name: Mouse Anti-Human IgG4 pFc’ [HP6023] (HRP) (ab99817) | Abcam
Brand: Abcam Limited
SKU: AB99817
Price: 56000 JPY
Availability: InStock

Be the first to review this product! Submit a review

(15 Publications)

Mouse Anti-Human IgG4 pFc’ (HRP) is a secondary antibody for chemiluminescent detection. Ideal for Western blot. Suitable for Western blot, IHC, ELISA, ICC and more.

- Cited in over 10 publications

別名を表示する

Immunoglobulin heavy constant gamma 4, Ig gamma-4 chain C region, IGHG4

1 Images

ELISA - Mouse Anti-Human IgG4 pFc’ [HP6023] (HRP) (AB99817)

ELISA

Supplier Data

ELISA - Mouse Anti-Human IgG4 pFc’ [HP6023] (HRP) (AB99817)

ELISA plate was coated with purified human IgG1, IgG2, IgG3, and IgG4. Immunoglobulins were detected with serially diluted ab99817.

Key facts

宿主種

Mouse

ターゲット種

Human

ターゲットアイソタイプ

IgG4

ターゲット特異性

Fc region

最小限の交差反応性

血清吸着処理済み

標識

HRP

励起波長/蛍光波長

アプリケーション

ICC, Dot, WB, ELISA, IHC-Fr

applications

クローン性

Monoclonal

クローン番号

HP6023

アイソタイプ

IgG3

軽鎖のタイプ

kappa

免疫原

Full Length Protein corresponding to Human IGHG4. The exact immunogen used to generate this antibody is proprietary information.

P01861

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "Dot": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"for Dot and slot immunoblotting." }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"" }, "ICC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"" }, "IHC-Fr": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"1/1000 - 1/2000", "notes":"" } } }

style

left-column

製品の詳細

This antibody reacts with the pFc' region of Human IgG4

When it comes to advancing your immunohistochemistry (IHC) research, Abcam offers comprehensive suite of IHC kits and secondary antibodies, designed to deliver precise and reliable results.

style

left-column

出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Protein A

バッファー組成

pH: 7.4 Constituents: PBS, 50% Glycerol (glycerin, glycerine)

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

+4°C

style

left-column

style

left-column

style

left-column

製品プロトコール

Visit the General protocols
Visit the Troubleshooting

style

left-column

ターゲットの情報

The protein expressed by the IGHG4 gene is part of the constant region of immunoglobulin heavy chains. Immunoglobulins, or antibodies, are glycoproteins produced by B lymphocytes that can be membrane-bound or secreted. During humoral immunity's recognition phase, membrane-bound immunoglobulins act as receptors. When they bind a specific antigen, they trigger B lymphocytes to undergo clonal expansion and differentiate into plasma cells that secrete immunoglobulins. These secreted immunoglobulins then mediate the effector phase of humoral immunity to eliminate the bound antigens. Each immunoglobulin possesses two antigen binding sites, formed by the variable domains of a heavy chain and an associated light chain, allowing for high affinity binding to specific antigens. These variable domains undergo V-(D)-J rearrangement and may experience somatic hypermutations, facilitating affinity maturation after antigen exposure and selection. This supplementary information is collated from multiple sources and compiled automatically.

See full target information IGHG4

style

left-column

文献 (15)

Recent publications for all applications. Explore the full list and refine your search

British journal of haematology : PubMed40386886

2025

Anti-HSP90α IgG may protect against antiphospholipid syndrome in systemic lupus erythematosus by reducing platelet activation.

Applications

Unspecified application

Species

Unspecified reactive species

Marina Barguil Macêdo,Andreas Jönsen,Anders A Bengtsson,Iva Gunnarsson,Elisabet Svenungsson,Christian Lood

Diabetes, obesity & metabolism 26:1395-1406 PubMed38287130

2024

Safety, tolerability, pharmacokinetic, pharmacodynamic and immunogenicity profiles of Exendin-4-IgG4-Fc in healthy subjects: A phase 1, single-centre, randomized, double-blind, dose escalation study.

Applications

Unspecified application

Species

Unspecified reactive species

Gui-Ling Chen,Yang Liu,Xue-Feng Gao,Kai-Qi Wu,Yun-Kai Yang,Yong Chen,Cong-Gao Peng,Ting-Han Jin,Yu-Bao Huang,Yao-Wen Zhang,Jing Su,Qi Jiang,Tong Guo,Jie Zhao,Xiang-Nan Peng,Jing-Yu Peng,Si-Xiu Li,Yong-Li Sun,Hong-Mei Zhang,Yan-Li Fu,Dan Luo,Yaru Ma,Zhen-Wei Shen,Yun-Tao Zhang,Zhang-Fei Shou

Nature immunology 24:869-883 PubMed37081150

2023

Orthogonal cytokine engineering enables novel synthetic effector states escaping canonical exhaustion in tumor-rejecting CD8 T cells.

Applications

Unspecified application

Species

Unspecified reactive species

Jesus Corria-Osorio,Santiago J Carmona,Evangelos Stefanidis,Massimo Andreatta,Yaquelin Ortiz-Miranda,Tania Muller,Ioanna A Rota,Isaac Crespo,Bili Seijo,Wilson Castro,Cristina Jimenez-Luna,Leonardo Scarpellino,Catherine Ronet,Aodrenn Spill,Evripidis Lanitis,Pedro Romero,Sanjiv A Luther,Melita Irving,George Coukos

PloS one 18:e0279389 PubMed36763580

2023

Increased number of T cells and exacerbated inflammatory pathophysiology in a human IgG4 knock-in MRL/lpr mouse model.

Applications

Unspecified application

Species

Unspecified reactive species

Yoshie Gon,Tsugumitsu Kandou,Tatsuaki Tsuruyama,Takeshi Iwasaki,Koji Kitagori,Kosaku Murakami,Ran Nakashima,Shuji Akizuki,Akio Morinobu,Masaki Hikida,Tsuneyo Mimori,Hajime Yoshifuji

Microbial cell factories 20:115 PubMed34107983

2021

Development of IL-15/IL-15Rα sushi domain-IgG4 Fc complexes in Pichia pastoris with potent activities and prolonged half-lives.

Applications

Unspecified application

Species

Unspecified reactive species

Huan Xu,Mingyang Shi,Changsheng Shao,Hao Li,Jing Wu,Yin Yu,Fang Fang,Yugang Guo,Weihua Xiao

Viruses 12: PubMed33138336

2020

Association of Genetic Polymorphisms in , , , and with the Clinical Forms of Dengue in Patients from Veracruz, Mexico.

Applications

Unspecified application

Species

Unspecified reactive species

Araceli Posadas-Mondragón,José Leopoldo Aguilar-Faisal,Gerardo Zuñiga,Jonathan Javier Magaña,José Angel Santiago-Cruz,Edith Guillén-Salomón,Verónica Alcántara-Farfán,María Luisa Arellano-Flores,Juan Santiago Salas-Benito,Rocío M Neri-Bazán,Lucero Luna-Rojas,Amanda Marineth Avila-Trejo,Adolfo Chávez-Negrete

Allergy 75:1835-1836 PubMed32652627

2020

Detection of peanut allergens in serum: circumventing the inhibitory effect of immunoglobulins.

Applications

Unspecified application

Species

Unspecified reactive species

Stef J Koppelman,Michel Witteveen,Lonneke JanssenDuijghuijsen,Joseph L Baumert,Renger F Witkamp,Klaske van Norren

Arthritis & rheumatology (Hoboken, N.J.) 72:687-693 PubMed31612628

2020

Disease Severity Linked to Increase in Autoantibody Diversity in IgG4-Related Disease.

Applications

Unspecified application

Species

Unspecified reactive species

Hang Liu,Cory A Perugino,Musie Ghebremichael,Zachary S Wallace,Sydney B Montesi,John H Stone,Shiv Pillai

Arteriosclerosis, thrombosis, and vascular biology 39:1884-1892 PubMed31315438

2019

Association Between ApoA-I (Apolipoprotein A-I) Immune Complexes and Adverse Cardiovascular Events-Brief Report.

Applications

Unspecified application

Species

Unspecified reactive species

David Henson,Ayman Samman Tahhan,David Nardo,Arshed Ali Quyyumi,Vincent J Venditto

Molecular medicine reports 18:5191-5197 PubMed30272291

2018

Emodin suppresses angiogenesis and metastasis in anaplastic thyroid cancer by affecting TRAF6‑mediated pathways in vivo and in vitro.

Applications

Unspecified application

Species

Unspecified reactive species

Guo-Hua Shi,Lin Zhou

View all publications

style

left-column

style

left-column

style

right-column

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Mouse Anti-Human IgG4 pFc’ [HP6023] (HRP)