Recombinant rat Cyclophilin F protein (Active) (His tag N-Terminus)

製品の性状

製品の状態

Liquid

補足情報

Purified by using conventional chromatography techniques.

一般的な情報

機能

PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (By similarity). Involved in regulation of the mitochondrial permeability transition pore (mPTP) (PubMed : 8567677, PubMed : 9309684, PubMed : 9820802). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated (PubMed : 8567677, PubMed : 9309684, PubMed : 9820802). In cooperation with mitochondrial p53/TP53 is involved in activating oxidative stress-induced necrosis (PubMed : 8567677, PubMed : 9309684, PubMed : 9820802). Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels (PubMed : 8567677, PubMed : 9309684, PubMed : 9820802). Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis (PubMed : 19228691).

配列の類似性

Belongs to the cyclophilin-type PPIase family.

翻訳後修飾

Acetylated at Lys-166; deacetylated at Lys-166 by SIRT3.

細胞内局在性

Mitochondrion matrix