Recombinant Mouse TREM2 protein (ab290832)
Key features and details
- Expression system: HEK 293 cells
- Purity: >= 95% HPLC
- Endotoxin level: <= 0.005 Eu/µg
- Suitable for: HPLC, SDS-PAGE
製品の詳細
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製品名
Recombinant Mouse TREM2 protein
TREM2 タンパク質・ペプチド 製品一覧 -
精製度
>= 95 % HPLC.
Purity by SDS-PAGE>=95% -
エンドトキシン・レベル
<=0.005 Eu/µg -
発現系
HEK 293 cells -
アクセッション番号
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タンパク質長
Full length protein -
Animal free
Yes -
キャリア・フリー
はい -
由来
Recombinant -
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生物種
Mouse -
配列
LNTTVLQGMAGQSLRVSCTYDALKHWGRRKAWCRQLGEEGPCQRVVSTHG VWLLAFLKKRNGSTVIADDTLAGTVTITLKNLQAGDAGLYQCQSLRGREA EVLQKVLVEVLEDPLDDQDAGDLWVPEESSSFEGAQVEHSTSRNQETSFP PTS -
予測される分子量
17 kDa -
実際の分子量
17 kDa -
分子量情報
Predicted MW is 16859 (+/- 10 Da by ESI-TOF). Observed MW is 16860.70 Da. -
領域
19 to 171 -
配列の追加情報
N-terminal glycine.
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特性
Our Abpromise guarantee covers the use of ab290832 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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アプリケーション
HPLC
SDS-PAGE
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製品の状態
Lyophilized -
Concentration information loading...
前処理および保存
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保存方法および安定性
Shipped at Room Temperature. Store at Room Temperature.
pH: 7.40
Constituents: 0.727% Dibasic monohydrogen potassium phosphate, 0.248% Monobasic dihydrogen potassium phosphate, 10.26% Trehalose -
再構成Lyophilized contents may appear as either a translucent film or a white powder. This variance does not affect the quality of the product. Store lyophilized form at room temperature. Reconstitute in phosphate buffered saline, aliquot and store at -80 °C for 12 months or +4 °C for 1 week. Avoid repeated freeze-thaw.
関連情報
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別名
- TREM 2
- TREM-2
- TREM2
see all -
機能
May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. -
組織特異性
Expressed on macrophages and dendritic cells but not on granulocytes or monocytes. In the CNS strongest expression seen in the basal ganglia, corpus callosum, medulla oblongata and spinal cord. -
関連疾患
Defects in TREM2 are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL) [MIM:221770]; also known as presenile dementia with bone cysts or Nasu-Hakola disease (NHD). PLOSL is a recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presenile dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most of the patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in the Finns. -
配列類似性
Contains 1 Ig-like V-type (immunoglobulin-like) domain. -
細胞内局在
Secreted and Cell membrane. - Information by UniProt
画像
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Mass Spectrometry - Recombinant Mouse TREM2 protein (ab290832)
Mass determination by ESI-TOF.
Predicted MW is 16859 Da (+/- 10 Da by ESI-TOF). Observed MW is 16860.70 Da.
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SDS-PAGE - Recombinant Mouse TREM2 protein (ab290832)SDS-PAGE analysis of ab290832.
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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Datasheet download
参考文献 (0)
ab290832 は論文での使用が確認できていません。
