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AB93068

Recombinant mouse PAI1 protein

Recombinant mouse PAI1 protein

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(1 Publication)

Recombinant mouse PAI1 protein is a Mouse Full Length protein, in the 24 to 402 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, FuncS.

別名を表示する

Mr1, Pai1, Planh1, Serpine1, Plasminogen activator inhibitor 1, PAI, PAI-1, Endothelial plasminogen activator inhibitor, Serpin E1

1 Images
SDS-PAGE - Recombinant mouse PAI1 protein (AB93068)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant mouse PAI1 protein (AB93068)

10% SDS-PAGE
Lane 1 : PAI1 (5 μg) Reduced
Lane 2 : PAI1 (5 μg) +uPA-HTC (8 μg) Reduced
Lane 3 : Prestained Standard

Key facts

精製度

>95% SDS-PAGE

発現系

Escherichia coli

タグ

Tag free

アプリケーション

FuncS, SDS-PAGE

applications

生物活性

Yes

生物学的活性

ab93068 is 80 (+/-) 5% active by uPA titration. The active fraction typically contains 70 percent active PAI1. Active concentration = ~2.0 mg/mL.

アクセッション番号

P22777

アニマルフリー

No

キャリアフリー

No

種

Mouse

バッファー組成

pH: 5 Constituents: 0.58% Sodium chloride, 0.41% Sodium acetate, 0.0292% EDTA

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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配列情報

[{"sequence":"LPLRESHTAHQATDFGVKVFQQVVQASKDRNVVFSPYGVSSVLAMLQMTTAGKTRRQIQDAMGFKVNEKGTAHALRQLSKELMGPWNKNEISTADAIFVQRDLELVQGFMPHFFKLFQTMVKQVDFSEVERARFIINDWVERHTKGMINDLLAKGAVDELTRLVLVNALYFSGQWKTPFLEASTHQRLFHKSDGSTVSVPMMAQSNKFNYTEFTTPDGLEYDVVELPYQGDTLSMFIAAPFEKDVHLSALTNILDAELIRQWKGNMTRLPRLLILPKFSLETEVDLRGPLEKLGMPDMFSATLADFTSLSDQEQLSVAQALQKVRIEVNESGTVASSSTAFVISARMAPTEMVIDRSFLFVVRHNPTETILFMGQVMEP","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":402,"aminoAcidStart":24,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P22777","tags":[]}]
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出荷温度及び保存条件

出荷温度
Dry Ice
短期保存温度
-80°C
長期保存温度
-80°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
True
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製品の性状

製品の状態

Liquid

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一般的な情報

機能

Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair (By similarity). Involved in cellular and replicative senescence (PubMed : 16862142). Plays a role in alveolar type 2 cells senescence in the lung (PubMed : 28722352). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (By similarity).

配列の類似性

Belongs to the serpin family.

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製品プロトコール

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ターゲットの情報

Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair (By similarity). Involved in cellular and replicative senescence (PubMed : 16862142). Plays a role in alveolar type 2 cells senescence in the lung (PubMed : 28722352). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (By similarity).
See full target information Serpine1
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

PloS one 14:e0221366 PubMed31442231

2019

Aging- and obesity-related peri-muscular adipose tissue accelerates muscle atrophy.

Applications

Unspecified application

Species

Unspecified reactive species

Shunshun Zhu,Zhe Tian,Daisuke Torigoe,Jiabin Zhao,Peiyu Xie,Taichi Sugizaki,Michio Sato,Haruki Horiguchi,Kazutoyo Terada,Tsuyoshi Kadomatsu,Keishi Miyata,Yuichi Oike
View all publications
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組合せ製品

Reagents, Controls & Accessories

AB234617

Prestained Protein Ladder - Mid-range molecular weight (10 - 180 kDa)

SDS-PAGE - Prestained Protein Ladder - Mid-range molecular weight (10 - 180 kDa) (AB234617)

  • 0
  • 0
Primary Antibodies

AB66705

Anti-PAI1 antibody

BOND RX™ Validated

Western blot - Anti-PAI1 antibody (AB66705)

  • 4
  • 8
Assay Kits

AB242296

Gamma H2A.X Staining Kit

Fluorescence Microscopy - Gamma H2A.X Staining Kit (AB242296)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Proteins & Peptides

AB217407

Recombinant human Vitronectin/S-Protein (Animal Free)

  • 0
  • 0

Abcam product promise

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