Recombinant mouse IL-1 alpha protein (ab9725)
Key features and details
- Expression system: Escherichia coli
- Purity: > 98% SDS-PAGE
- Active: Yes
- Suitable for: Functional Studies, SDS-PAGE
製品の詳細
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製品名
Recombinant mouse IL-1 alpha protein
IL-1 alpha タンパク質・ペプチド 製品一覧 -
精製度
> 98 % SDS-PAGE.
Sterile filtered Greater than 98% pure by HPLC analyses. Endotoxin level is less than 0.1 ng per g (1EU/g). -
発現系
Escherichia coli -
アクセッション番号
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タンパク質長
Full length protein -
Animal free
No -
由来
Recombinant -
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生物種
Mouse -
配列
Recombinant Murine IL-1a is a 17.9 kDa protein containing 156 amino acid residues: SAPYTYQSDL RYKLMKLVRQ KFVMNDSLNQ TIYQ DVDKHY LSTTWLNDLQ QEVKFDMYAYSSGGDDSKYP VTLKISDSQL FVSAQGEDQP VLLKELPETP KLITGSETDL IFFWKSINSKNYFTSAA YPE LFIATKEQSR VHLARGLPSM TDFQIS
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特性
Our Abpromise guarantee covers the use of ab9725 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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アプリケーション
Functional Studies
SDS-PAGE
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製品の状態
Lyophilized -
備考
The ED50, determined by the dose-dependent stimulation of murine D10S cells, is < 0.002 ng/ml, corresponding to a specific activity of > 5 x 108 units/mg. -
Concentration information loading...
前処理および保存
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保存方法および安定性
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
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再構成For lot specific reconstitution information please contact our Scientific Support Team.
関連情報
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別名
- BAF
- FAF
- Hematopoietin 1
see all -
機能
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. -
配列類似性
Belongs to the IL-1 family. -
ドメイン
The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function. -
細胞内局在
Secreted. The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. - Information by UniProt
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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Datasheet download
参考文献 (1)
ab9725 は 1 報の論文で使用されています。
- Dahllöf MS et al. The lysine deacetylase inhibitor Givinostat inhibits ß-cell IL-1ß induced IL-1ß transcription and processing. Islets 4:417-22 (0). PubMed: 23486342
