Recombinant Mouse Cathepsin B protein (His tag C-Terminus)
Recombinant Mouse Cathepsin B protein (His tag C-Terminus)
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Recombinant Mouse Cathepsin B protein (His tag C-Terminus) is a Mouse Full Length protein, in the 18 to 339 aa range, expressed in Baculovirus infected insect cells, with >90%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.
別名を表示する
Cathepsin B, Cathepsin B1, Ctsb
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Mouse Cathepsin B protein (His tag) (AB219240)
15% SDS-PAGE analysis of 3 μg ab219240.
Molecular Weight : 28-40kDa (SDS-PAGE under reducing conditions).
Reactivity data
配列情報
出荷温度及び保存条件
出荷温度
短期保存期間
短期保存温度
長期保存温度
分注に関する情報
保管に関する情報
補足情報
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Cathepsin B participates as a proteolytic enzyme involved in protein turnover and processing. It does not function in isolation but often associates with various other proteases forming complexes essential for efficient substrate breakdown. Cathepsin B assists in the activation of other enzymes by cleaving propeptides therefore facilitating the initiation of cascade reactions. This role is critical in maintaining cellular homeostasis and modulating physiological processes including cell migration and immune response modulation.
Pathways
Cathepsin B significantly contributes to the lysosomal protein degradation pathway and the autophagy-lysosome pathway. It interacts with proteins such as B protein which are important for cellular recycling and energy homeostasis. Its activity supports the MHC class II antigen processing pathway playing an essential part in immune system functionality. Cathepsin B also exhibits interactions with Ctsb protein inhibitors which regulate its proteolytic activity within these pathways.
製品の性状
製品の状態
Liquid
補足情報
Affinity purified
一般的な情報
機能
Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (By similarity). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (PubMed : 12782676). Has also been implicated in tumor invasion and metastasis (By similarity).
配列の類似性
Belongs to the peptidase C1 family.
細胞内局在性
Lysosome
ターゲットの情報
Abcam product promise
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