AB151916

Recombinant Human Zinc Alpha 2 Glycoprotein

Name: Recombinant Human Zinc Alpha 2 Glycoprotein (ab151916) | Abcam
Brand: Abcam Limited
SKU: AB151916
Price: 54000 JPY
Availability: InStock

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(1 Publication)

Recombinant Human Zinc Alpha 2 Glycoprotein is a Human Full Length protein, in the 21 to 298 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, HPLC.

別名を表示する

ZAG, ZNGP1, AZGP1, Zinc-alpha-2-glycoprotein, Zn-alpha-2-GP, Zn-alpha-2-glycoprotein

Key facts

精製度

>95% SDS-PAGE

Purity is greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.

エンドトキシンレベル

< 1 EU/µg

発現系

HEK 293 cells

アプリケーション

HPLC, SDS-PAGE

applications

生物活性

アクセッション番号

P25311

アニマルフリー

キャリアフリー

種

Human

再構成

Reconstitute in PBS

バッファー組成

pH: 7.5 Constituents: 0.88% Sodium chloride, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "HPLC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

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配列情報

[{"linker":null,"sequence":"QENQDGRYSLTYIYTGLSKHVEDVPAFQALGSLNDLQFFRYNSKDRKSQPMGLWRQVEGMEDWKQDSQLQKAREDIFMETLKDIVEYYNDSNGSHVLQGRFGCEIENNRSSGAFWKYYYDGKDYIEFNKEIPAWVPFDPAAQITKQKWEAEPVYVQRAKAYLEEECPATLRKYLKYSKNILDRQDPPSVVVTSHQAPGEKKKLKCLAYDFYPGKIDVHWTRAGEVQEPELRGDVLHNGNGTYQSWVVVAVPPQDTAPYSCHVQHSSLAQPLVVPWEASVDHHHHHH","proteinLength":"Full Length","predictedMolecularWeight":"33.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":298,"aminoAcidStart":21,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"P25311","tags":[{"tag":"His","terminus":"C-Terminus"}]}]

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出荷温度及び保存条件

製品の状態

Lyophilized

出荷温度

Blue Ice

短期保存期間

A few weeks

短期保存温度

-20°C

長期保存温度

-20°C

False

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Zinc Alpha 2 Glycoprotein (ZAG) also called ZAG or AZGP1 is a soluble protein with a molecular mass of approximately 41 kDa. It functions as an adipokine and is mostly found in the liver breast and prostate tissues as well as in bodily fluids like plasma and saliva. ZAG belongs to the major histocompatibility complex class I family and it shares structural similarities with antigen-presenting proteins.

Biological function summary

Zinc Alpha 2 Glycoprotein assists in lipid metabolism. It promotes the breakdown of triglycerides in adipose tissue by stimulating the beta-adrenergic pathway. ZAG functions independently and does not typically form complexes with other proteins during this process. Its presence in adipose tissue suggests a role in energy homeostasis and body weight regulation.

Pathways

Zinc Alpha 2 Glycoprotein participates in the metabolic pathway for lipid degradation. The protein interacts with beta-3 adrenergic receptors to trigger lipolysis which involves breaking down fat cells into free fatty acids and glycerol. Its action in this pathway links ZAG with other proteins such as perilipin which protects lipid droplets from breakdown.

Zinc Alpha 2 Glycoprotein has connections with metabolic-related conditions notably obesity and cancer cachexia. In obesity lower levels of ZAG are often observed potentially linking it to impaired fat metabolism. In cancer cachexia elevated ZAG levels are frequently detected suggesting a role in the loss of fat and muscle tissue. ZAG's interaction with certain cytokines may enhance cachexia progression by affecting protein degradation pathways.

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一般的な情報

機能

Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids.

配列の類似性

Belongs to the MHC class I family.

翻訳後修飾

N-glycosylated. N-glycan at Asn-128: Hex5HexNAc4.

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製品プロトコール

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids.

See full target information AZGP1

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of cellular physiology 231:2622-7 PubMed27137486

2016

Prototype of Multiplex Bead Assay for Quantification of Three Serum Biomarkers for In Vitro Diagnosis of Endometriosis.

Applications

Unspecified application

Species

Unspecified reactive species

Pietro Giulio Signorile,Alfonso Baldi

View all publications

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Abcam product promise

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Recombinant Human Zinc Alpha 2 Glycoprotein