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AB140057

Recombinant Human YKL-40/CHI3L1 protein (His tag C-Terminus + Myc tag C-Terminus)

Recombinant Human YKL-40/CHI3L1 protein (His tag C-Terminus + Myc tag C-Terminus)

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Recombinant Human YKL-40/CHI3L1 protein (His tag C-Terminus + Myc tag C-Terminus) is a Human Full Length protein, in the 22 to 383 aa range, expressed in CHO cells, with >90%, suitable for SDS-PAGE.

別名を表示する

Chitinase-3-like protein 1, 39 kDa synovial protein, Cartilage glycoprotein 39, YKL-40, CGP-39, GP-39, hCGP-39, CHI3L1

1 Images
SDS-PAGE - Recombinant Human YKL-40/CHI3L1 protein (His tag C-Terminus + Myc tag C-Terminus) (AB140057)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human YKL-40/CHI3L1 protein (His tag C-Terminus + Myc tag C-Terminus) (AB140057)

15% SDS-PAGE analysis of ab140057 (3µg).

Key facts

精製度

>90% SDS-PAGE

発現系

CHO cells

タグ

His tag C-Terminus Myc tag C-Terminus

アプリケーション

SDS-PAGE

applications

生物活性

No

アクセッション番号

P36222

アニマルフリー

No

キャリアフリー

No

種

Human

バッファー組成

pH: 7.4 Constituents: PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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製品の詳細

Previously labelled as CHI3L1
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配列情報

[{"sequence":"YKLVCYYTSWSQYREGDGSCFPDALDRFLCTHIIYSFANISNDHIDTWEWNDVTLYGMLNTLKNRNPNLKTLLSVGGWNFGSQRFSKIASNTQSRRTFIKSVPPFLRTHGFDGLDLAWLYPGRRDKQHFTTLIKEMKAEFIKEAQPGKKQLLLSAALSAGKVTIDSSYDIAKISQHLDFISIMTYDFHGAWRGTTGHHSPLFRGQEDASPDRFSNTDYAVGYMLRLGAPASKLVMGIPTFGRSFTLASSETGVGAPISGPGIPGRFTKEAGTLAYYEICDFLRGATVHRILGQQVPYATKGNQWVGYDDQESVKSKVQYLKDRQLAGAMVWALDLDDFQGSFCGQDLRFPLTNAIKDALAATKLGPEQKLISEEDLNSAVDHHHHHH","proteinLength":"Full Length","predictedMolecularWeight":"43.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":383,"aminoAcidStart":22,"nature":"Recombinant","expressionSystem":"CHO cells","accessionNumber":"P36222","tags":[{"tag":"His","terminus":"C-Terminus"},{"tag":"Myc","terminus":"C-Terminus"}]}]
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出荷温度及び保存条件

出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
False
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

YKL-40 also known as chitinase-3-like protein 1 (CHI3L1) is a glycoprotein with a molecular weight of approximately 40 kDa. Scientists often study it for its roles in inflammatory processes. It has expressions in numerous tissues including liver cartilage and the central nervous system. The CHI3L1 protein does not possess chitinase activity unlike other members of the chitinase family yet it interacts with various ligands to influence cellular behavior.
Biological function summary

YKL-40 plays significant roles in tissue remodeling and inflammation. It does not form part of a larger complex by itself but influences several cellular processes. This protein affects cell proliferation migration and survival making it involved in both normal physiological processes and pathological conditions. CHI3L1 also exhibits a connection to the immune response where it modulates macrophage activity and interacts with other immune cells.

Pathways

YKL-40 is integral to the inflammatory and extracellular matrix pathways. It associates with proteins such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) influencing signaling cascades that modulate inflammation. Through these interactions CHI3L1 becomes a mediator of connective tissue metabolism and immune reactions in various pathophysiological states.

YKL-40 shows strong links to conditions like osteoarthritis and certain cancers. In osteoarthritis elevated levels of CHI3L1 reflect increased cartilage degradation while in oncology it correlates with tumor angiogenesis and metastasis potential. Its connection with proteins such as matrix metalloproteinases highlights its role in disease mechanisms highlighting its potential as a biomarker for early detection and disease progression monitoring.
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製品の性状

製品の状態

Liquid

補足情報

ab140057 was purified by using conventional chromatography techniques.

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一般的な情報

機能

Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung.

配列の類似性

Belongs to the glycosyl hydrolase 18 family.

翻訳後修飾

Glycosylated.

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製品プロトコール

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ターゲットの情報

Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung.
See full target information CHI3L1
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組合せ製品

Primary Antibodies

AB77528

Anti-YKL-40/CHI3L1 antibody

BOND RX™ Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-YKL-40/CHI3L1 antibody (AB77528)

  • 4
  • 3
Assay Kits

AB255719

Human YKL-40 ELISA Kit

Recombinant|SimpleStep

ELISA - Human YKL-40 ELISA Kit (AB255719)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Assay Kits

AB256754

Human YKL-40 Antibody Pair - BSA and Azide free

RabMAb|Recombinant

Sandwich ELISA - Human YKL-40 Antibody Pair - BSA and Azide free (AB256754)

  • 0
  • 0

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