JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB177641

Recombinant Human XRCC2 protein (denatured) (His tag N-Terminus)

Recombinant Human XRCC2 protein (denatured) (His tag N-Terminus)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human XRCC2 protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 1 to 280 aa range, expressed in Escherichia coli, with >80%, suitable for SDS-PAGE.

別名を表示する

DNA repair protein XRCC2, X-ray repair cross-complementing protein 2, XRCC2

1 Images
SDS-PAGE - Recombinant Human XRCC2 protein (denatured) (His tag N-Terminus) (AB177641)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human XRCC2 protein (denatured) (His tag N-Terminus) (AB177641)

15% SDS-PAGE analysis of ab177641 (3ug)

Key facts

精製度

>80% SDS-PAGE

発現系

Escherichia coli

タグ

His tag N-Terminus

アプリケーション

SDS-PAGE

applications

生物活性

No

アクセッション番号

O43543

アニマルフリー

No

キャリアフリー

No

種

Human

バッファー組成

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris-HCl buffer

storage-buffer

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

配列情報

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMCSAFHRAESGTELLARLEGRSSLKEIEPNLFADEDSPVHGDILEFHGPEGTGKTEMLYHLTARCILPKSEGGLEVEVLFIDTDYHFDMLRLVTILEHRLSQSSEEIIKYCLGRFFLVYCSSSTHLLLTLYSLESMFCSHPSLCLLILDSLSAFYWIDRVNGGESVNLQESTLRKCSQCLEKLVNDYRLVLFATTQTIMQKASSSSEEPSHASRRLCDVDIDYRPYLCKAWQQLVKHRMFFSKQDDSQSSNQFSLVSRCLKSNSLKKHFFIIGESGVEFC","proteinLength":"Full Length","predictedMolecularWeight":"34.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":280,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O43543","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
style
left-column

出荷温度及び保存条件

出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
False
style
left-column

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

XRCC2 also known as X-ray repair cross-complementing protein 2 is a protein that plays a role in DNA repair mechanisms. It has a molecular mass of approximately 33 kDa. XRCC2 is expressed in various tissues with noticeable abundance in proliferative tissues due to their high demand for DNA repair processes. Mechanistically XRCC2 functions as part of the Rad51 paralog group facilitating homologous recombination repair of DNA double-strand breaks. Its involvement is quintessential for maintaining genomic stability.
Biological function summary

XRCC2 contributes to cellular maintenance by repairing DNA double-strand breaks through the homologous recombination pathway. It participates in the Rad51 paralog complex alongside other paralogs like Rad51B Rad51C Rad51D and XRCC3. This complex ensures precise repair and re-ligation of damaged DNA by assisting in strand exchange and stabilization. Such actions highlight XRCC2's role in preserving cell genetic integrity and preventing mutations.

Pathways

Homologous recombination and DNA repair are integral processes where XRCC2 operates. The homologous recombination pathway is critically linked with the maintenance of chromosome integrity during cell division. XRCC2 by cooperating with proteins like RAD51 and BRCA2 forms an essential part of recombinational DNA repair. Its interactions are necessary for orchestrating the repair process ensuring seamless recovery of the genetic code after disruptions.

XRCC2 is associated closely with cancer vulnerabilities due to its role in DNA repair. Deficiencies or mutations in XRCC2 can lead to increased susceptibility to tumors and hereditary breast cancer given its involvement in stabilizing RAD51 function which is pivotal in suppressing tumor formation. The malfunction in XRCC2's DNA repair capabilities can also have connections with Fanconi anemia highlighting XRCC2’s importance to genetic disorders related to impaired DNA repair mechanisms.
style
left-column

製品の性状

製品の状態

Liquid

style
left-column

一般的な情報

機能

Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.

配列の類似性

Belongs to the RecA family. RAD51 subfamily.

細胞内局在性

Nucleus

style
left-column

製品プロトコール

style
left-column

ターゲットの情報

Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.
See full target information XRCC2
style
left-column
style
left-column
style
right-column

組合せ製品

Proteins & Peptides

AB174559

Recombinant Human SSSCA1 protein (denatured) (His tag N-Terminus)

SDS-PAGE - Recombinant Human SSSCA1 protein (denatured) (His tag N-Terminus) (AB174559)

  • 0
  • 0
Proteins & Peptides

AB177632

Recombinant Human Ubiquinol-Cytochrome C Reductase Core Protein I (denatured) (His tag N-Terminus)

SDS-PAGE - Recombinant Human Ubiquinol-Cytochrome C Reductase Core Protein I (denatured) (His tag N-Terminus) (AB177632)

  • 0
  • 0
Proteins & Peptides

AB176082

Recombinant Human CGT protein (denatured) (His tag N-Terminus)

SDS-PAGE - Recombinant Human CGT protein (denatured) (His tag N-Terminus) (AB176082)

  • 0
  • 0
Proteins & Peptides

AB177610

Recombinant Human SKA1 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human SKA1 protein (His tag N-Terminus) (AB177610)

  • 0
  • 0

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com