Recombinant Human ULBP2 protein (Fc Chimera) (ab185428)
Key features and details
- Expression system: Mammalian
- Purity: > 95% SDS-PAGE
- Endotoxin level: < 1.000 Eu/µg
- Tags: Fc tag C-Terminus
- Suitable for: SDS-PAGE, HPLC
製品の詳細
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製品名
Recombinant Human ULBP2 protein (Fc Chimera)
ULBP2 タンパク質・ペプチド 製品一覧 -
精製度
> 95 % SDS-PAGE.
Determined by SEC-HPLC and reducing SDS-PAGE. -
エンドトキシン・レベル
< 1.000 Eu/µg -
発現系
Mammalian -
アクセッション番号
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タンパク質長
Full length protein -
Animal free
No -
由来
Recombinant -
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生物種
Human -
配列
GRADPHSLCYDITVIPKFRPGPRWCAVQGQVDEKTFLHYDCGNKTVTPVS PLGKKLNVTTAWKAQNPVLREVVDILTEQLRDIQLENYTPKEPLTLQARM SCEQKAEGHSSGSWQFSFDGQIFLLFDSEKRMWTTVHPGARKMKEKWEND KVVAMSFHYFSMGDCIGWLEDFLMGMDSTLEPSAGAPLAMSS -
予測される分子量
22 kDa -
領域
26 to 217 -
タグ
Fc tag C-Terminus -
配列の追加情報
Mature protein. C terminal FC tag.
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関連製品
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Related Products
特性
Our Abpromise guarantee covers the use of ab185428 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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アプリケーション
SDS-PAGE
HPLC
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製品の状態
Lyophilized -
Concentration information loading...
前処理および保存
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保存方法および安定性
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle. Reconstitute for long term storage.
pH: 7.40
Constituent: 100% PBS
Lyophilized from an 0.2 µM filtered solution. -
再構成Dissolve the lyophilized protein in 3X PBS. It is not recommended to reconstitute to a concentration less than 100 µg/ml. Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
関連情報
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別名
- ALCAN alpha
- ALCAN-alpha
- N2DL 2
see all -
機能
Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. -
組織特異性
Expressed in various types of cancer cell lines and in the fetus, but not in normal tissues. -
配列類似性
Belongs to the MHC class I family. -
細胞内局在
Cell membrane. Secreted. - Information by UniProt
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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Datasheet download
参考文献 (0)
ab185428 は論文での使用が確認できていません。
