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AB134517

Recombinant Human ULBP1 protein (His tag N-Terminus)

Recombinant Human ULBP1 protein (His tag N-Terminus)

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Recombinant Human ULBP1 protein (His tag N-Terminus) is a Human Full Length protein, in the 26 to 216 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

別名を表示する

N2DL1, RAET1I, ULBP1, UL16-binding protein 1, ALCAN-beta, NKG2D ligand 1, Retinoic acid early transcript 1I, N2DL-1, NKG2DL1

1 Images
SDS-PAGE - Recombinant Human ULBP1 protein (His tag N-Terminus) (AB134517)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human ULBP1 protein (His tag N-Terminus) (AB134517)

15% SDS-PAGE analysis of ab134517 (3ug)

Key facts

精製度

>90% SDS-PAGE

ab134517 is purified by using conventional chromatography techniques.

発現系

Escherichia coli

タグ

His tag N-Terminus

アプリケーション

SDS-PAGE, Mass Spec

applications

生物活性

No

アクセッション番号

Q9BZM6

アニマルフリー

No

キャリアフリー

No

種

Human

バッファー組成

pH: 8 Constituents: 30% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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組合せ製品

Proteins & Peptides

AB128443

Recombinant Human ULBP2 protein (denatured) (His tag N-Terminus)

SDS-PAGE - Recombinant Human ULBP2 protein (denatured) (His tag N-Terminus) (AB128443)

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Proteins & Peptides

AB313356

Recombinant Human IDO1 Protein (His tag) (E.Coli)

Mass Spectrometry - Recombinant Human IDO1 Protein (His tag) (E.Coli) (AB313356)

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  • 0
Primary Antibodies

AB311847

Anti-Indoleamine 2, 3-dioxygenase antibody [EPR28349-89]

BOND RX™ Validated|20ul selling size|KO Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Indoleamine 2, 3-dioxygenase antibody [EPR28349-89] (AB311847)

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Primary Antibodies

AB62540

Anti-MICA antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MICA antibody (AB62540)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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配列情報

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMGSHMGWVDTHCLCYDFIITPKSRPEPQWCEVQGLVDERPFLHYDCVNHKAKAFASLGKKVNVTKTWEEQTETLRDVVDFLKGQLLDIQVENLIPIEPLTLQARMSCEHEAHGHGRGSWQFLFNGQKFLLFDSNNRKWTALHPGAKKMTEKWEKNRDVTMFFQKISLGDCKMWLEEFLMYWEQMLDPTKPPSLAPG","proteinLength":"Full Length","predictedMolecularWeight":"25 kDa","actualMolecularWeight":null,"aminoAcidEnd":216,"aminoAcidStart":26,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9BZM6","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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出荷温度及び保存条件

製品の状態
Liquid
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
False
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

ULBP1 also known as UL16-binding protein 1 is a member of the MHC class I-related molecules. It weighs approximately 28 kDa. ULBP1 acts mechanically as a ligand for the NKG2D receptor part of the activating receptor on natural killer (NK) cells and certain T cells. It is primarily expressed on the surface of various cells including epithelial and some tumor cells. Its expression can be induced by cellular stress or infection.
Biological function summary

This protein plays a critical role in immune surveillance and response to malignancies and infections. ULBP1 does not form a complex on its own but it works closely with other NKG2D ligands contributing to the immune system's ability to recognize and eliminate abnormal cells. Its presence can enhance immune cell-mediated cytotoxicity indicating its role in immune defense.

Pathways

The protein takes an active part in the immune system activation interacting notably within the NK cell-mediated cytotoxicity pathway. It functions alongside other NKG2D ligands like MICA/MICB to modulate the activity of NK cells and T cells. This connection to the NKG2D pathway ensures a critical interface between innate and adaptive immunity reinforcing defense against infected or tumor cells.

Researchers have noted associations between ULBP1 and cancer progression or immune evasion. Its upregulation on tumor cells can lead to tumor clearance; however some cancers may shed ULBP1 to escape immune detection. In autoimmune diseases such as rheumatoid arthritis altered expression of ULBP1 and its interaction with NKG2D can potentially exacerbate inflammation. These interactions emphasize the balance that ULBP1 maintains in managing immune responses and its implications in pathology.
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一般的な情報

機能

Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.

配列の類似性

Belongs to the MHC class I family.

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製品プロトコール

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ターゲットの情報

Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
See full target information ULBP1
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