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AB167847

Recombinant Human UBXN2B protein (His tag N-Terminus)

Recombinant Human UBXN2B protein (His tag N-Terminus)

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Recombinant Human UBXN2B protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 331 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

別名を表示する

UBX domain-containing protein 2B, NSFL1 cofactor p37, p97 cofactor p37, UBXN2B

1 Images
SDS-PAGE - Recombinant Human UBXN2B protein (His tag N-Terminus) (AB167847)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human UBXN2B protein (His tag N-Terminus) (AB167847)

15% SDS-PAGE analysis of 3µg ab167847.

Key facts

精製度

>90% SDS-PAGE

発現系

Escherichia coli

タグ

His tag N-Terminus

アプリケーション

Mass Spec, SDS-PAGE

applications

生物活性

No

アクセッション番号

Q14CS0

アニマルフリー

No

キャリアフリー

No

種

Human

バッファー組成

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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配列情報

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMAEGGGPEPGEQERRSSGPRPPSARDLQLALAELYEDEVKCKSSKSNRPKATVFKSPRTPPQRFYSSEHEYSGLNIVRPSTGKIVNELFKEAREHGAVPLNEATRASGDDKSKSFTGGGYRLGSSFCKRSEYIYGENQLQDVQILLKLWSNGFSLDDGELRPYNEPTNAQFLESVKRGEIPLELQRLVHGGQVNLDMEDHQDQEYIKPRLRFKAFSGEGQKLGSLTPEIVSTPSSPEEEDKSILNAVVLIDDSVPTTKIQIRLADGSRLIQRFNSTHRILDVRNFIVQSRPEFAALDFILVTSFPNKELTDESLTLLEADILNTVLLQQLK","proteinLength":"Full Length","predictedMolecularWeight":"39.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":331,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q14CS0","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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出荷温度及び保存条件

出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
False
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

UBXN2B also known as UBX domain-containing protein 2B is a human protein with a molecular mass of approximately 60 kDa. It contains a UBX domain that enables interactions with various cellular components. UBXN2B is largely expressed in the cytoplasm and nucleus of cells. The protein acts as an adaptor in the ubiquitin-proteasome system facilitating the delivery of ubiquitinated substrates for degradation. It also interacts with p97/VCP an important AAA ATPase involved in extracting misfolded proteins.
Biological function summary

UBXN2B plays a significant role in the endoplasmic reticulum-associated degradation (ERAD) pathway managing protein quality control. It is an essential part of protein complexes that regulate ER-associated protein degradation. These complexes ensure proper folding and elimination of misfolded proteins which helps maintain cellular homeostasis. Lack of proper function of such complexes can lead to accumulation of defective proteins impacting cell health.

Pathways

UBXN2B participates in the protein degradation pathways including the ERAD and ubiquitin-proteasome pathways. It works closely with the p97/VCP complex to recognize and dismantle faulty proteins. UBXN2B also associates with other proteins in the degradation system such as ubiquitin ligases which tag unwanted proteins for destruction. This facilitates the cycling and reuse of cellular components essential for cellular metabolism and function.

UBXN2B has been linked to neurodegenerative diseases and cancer. Misregulation may contribute to conditions like Parkinson’s disease where protein aggregation negatively affects neurons. In certain cancers altered UBXN2B expression influences tumor growth by disrupting normal protein degradation pathways. These conditions often involve proteins like p97/VCP which under normal circumstances works with UBXN2B to maintain cellular proteostasis.
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製品の性状

製品の状態

Liquid

補足情報

ab167847 was purified using conventional chromatography techniques.

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一般的な情報

機能

Adapter protein required for Golgi and endoplasmic reticulum biogenesis (PubMed : 17141156). Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis (PubMed : 17141156). The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L (PubMed : 17141156). VCPIP1 is also required, but not its deubiquitinating activity (PubMed : 17141156). Together with NSFL1C/p47, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed : 23649807). Also, regulates spindle orientation during mitosis (PubMed : 23649807).

配列の類似性

Belongs to the NSFL1C family.

細胞内局在性

Nucleus

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製品プロトコール

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ターゲットの情報

Adapter protein required for Golgi and endoplasmic reticulum biogenesis (PubMed : 17141156). Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis (PubMed : 17141156). The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L (PubMed : 17141156). VCPIP1 is also required, but not its deubiquitinating activity (PubMed : 17141156). Together with NSFL1C/p47, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed : 23649807). Also, regulates spindle orientation during mitosis (PubMed : 23649807).
See full target information UBXN2B
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組合せ製品

Primary Antibodies

AB124032

Anti-UBXN2B antibody [OTI3H8]

Flow Cytometry (Intracellular) - Anti-UBXN2B antibody [OTI3H8] (AB124032)

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