AB194018

Recombinant Human TXNDC15 protein

Name: Recombinant Human TXNDC15 protein (ab194018) | Abcam
Brand: Abcam Limited
SKU: AB194018
Price: 126000 JPY
Availability: InStock

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Recombinant Human TXNDC15 protein is a Human Fragment protein, in the 33 to 321 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, HPLC.

別名を表示する

C5orf14, UNQ335/PRO534, TXNDC15, Thioredoxin domain-containing protein 15

Key facts

精製度

>95% SDS-PAGE

エンドトキシンレベル

< 1 EU/µg

発現系

HEK 293 cells

アプリケーション

SDS-PAGE, HPLC

applications

生物活性

アクセッション番号

Q96J42

アニマルフリー

キャリアフリー

種

Human

バッファー組成

pH: 7.4 Constituents: 99% Phosphate Buffer, 0.87% Sodium chloride

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "HPLC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

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配列情報

[{"sequence":"VEVAEESGRLWSEEQPAHPLQVGAVYLGEEELLHDPMGQDRAAEEANAVLGLDTQGDHMVMLSVIPGEAEDKVSSEPSGVTCGAGGAEDSRCNVRESLFSLDGAGAHFPDREEEYYTEPEVAESDAAPTEDSNNTESLKSPKVNCEERNITGLENFTLKILNMSQDLMDFLNPNGSDCTLVLFYTPWCRFSASLAPHFNSLPRAFPALHFLALDASQHSSLSTRFGTVAVPNILLFQGAKPMARFNHTDRTLETLKIFIFNQTGIEAKKNVVVTQADQIGPLPSTLIKSVDHHHHHH","proteinLength":"Fragment","predictedMolecularWeight":"32.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":321,"aminoAcidStart":33,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q96J42","tags":[{"tag":"His","terminus":"C-Terminus"}]}]

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出荷温度及び保存条件

出荷温度

Blue Ice

短期保存温度

-20°C

長期保存温度

-20°C

False

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

TXNDC15 also known as Thioredoxin Domain Containing 15 is a protein with a mass of approximately 34 kDa. It functions mechanically as a member of the thioredoxin-like protein family which plays a role in redox reactions. TXNDC15 is expressed in various tissues including the liver heart and placenta. The protein's primary role involves maintaining cellular redox homeostasis by facilitating disulfide bond formation and isomerization.

Biological function summary

TXNDC15 participates in cellular processes related to oxidative stress response and protein folding. It does not act alone and is often seen as part of larger protein complexes involved in the reduction of oxidized proteins. By ensuring correct protein folding and preventing aggregation TXNDC15 contributes to efficient cellular function. This activity is critical in maintaining the balance between oxidation and reduction in the cell environment.

Pathways

TXNDC15 engages in the thioredoxin pathway and protein disulfide isomerase pathway. These pathways are integral in managing oxidative stress and ensuring correct protein folding. TXNDC15 interacts with proteins such as TXN and PDI which assist it in managing disulfide bond rearrangement and maintaining proper cell function. These interactions place TXNDC15 in a relevant position within the cellular machinery that combats oxidative damage.

TXNDC15 associates with conditions such as cancer and neurodegenerative diseases. Its role in maintaining protein homeostasis directly impacts disease progression where aberrant protein expression can disrupt cellular health. In cancer interactions with proteins like Nrf2 facilitate the oxidative stress response which some tumors exploit for survival. Similarly in neurodegenerative diseases TXNDC15 helps protect against oxidative damage with implications for proteins like superoxide dismutase known to play in disorder progression.

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製品の性状

製品の状態

Lyophilized

補足情報

Purity is greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.

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一般的な情報

機能

Acts as a positive regulator of ciliary hedgehog signaling (By similarity). Involved in ciliogenesis (PubMed : 27894351).

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製品プロトコール

Visit the General protocols
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ターゲットの情報

Acts as a positive regulator of ciliary hedgehog signaling (By similarity). Involved in ciliogenesis (PubMed : 27894351).

See full target information TXNDC15

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Abcam product promise

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Recombinant Human TXNDC15 protein