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AB131704

Recombinant Human TULP1 protein

Recombinant Human TULP1 protein

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Recombinant Human TULP1 protein is a Human Fragment protein, in the 290 to 542 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

別名を表示する

TUBL1, TULP1, Tubby-related protein 1, Tubby-like protein 1

1 Images
SDS-PAGE - Recombinant Human TULP1 protein (AB131704)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human TULP1 protein (AB131704)

15% SDS-PAGE showing ab131704 at approximately 31.1 kDa (3µg).

Key facts

精製度

>90% SDS-PAGE

発現系

Escherichia coli

タグ

His tag N-Terminus

アプリケーション

SDS-PAGE, Mass Spec

applications

生物活性

No

アクセッション番号

O00294

アニマルフリー

No

キャリアフリー

No

種

Human

バッファー組成

pH: 8 Constituents: 50% Glycerol (glycerin, glycerine), 1.17% Sodium chloride, 0.32% Tris HCl, 0.08% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.06% EDTA

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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配列情報

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSEPREFVLRPAPQGRTVRCRLTRDKKGMDRGMYPSYFLHLDTEKKVFLLAGRKRKRSKTANYLISIDPTNLSRGGENFIGKLRSNLLGNRFTVFDNGQNPQRGYSTNVASLRQELAAVIYETNVLGFRGPRRMTVIIPGMSAENERVPIRPRNASDGLLVRWQNKTLESLIELHNKPPVWNDDSGSYTLNFQGRVTQASVKNFQIVHADDPDYIVLQFGRVAEDAFTLDYRYPLCALQAFAIALSSFDGKLACE","proteinLength":"Fragment","predictedMolecularWeight":"31.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":542,"aminoAcidStart":290,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O00294","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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出荷温度及び保存条件

出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
False
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The TULP1 protein also known as TUB-like protein 1 is a 64 kDa protein primarily expressed in retinal tissue. This protein has a significant role in intracellular trafficking pathways. Mechanically TULP1 interacts with other proteins to ensure the proper transport of photoreceptor-specific cargo. This interaction contributes to maintaining cellular function by keeping the photoreceptor cells healthy.
Biological function summary

TULP1 is critical for the photoreceptor cells' viability and functionality. It does not operate as a solitary entity but rather as a part of a larger molecular complex involved in managing the phototransduction pathways. By partnering with various molecules TULP1 mediates the movement and turnover of phototransduction components helping to maintain the cell structure and promote vision stability.

Pathways

TULP1 plays a significant role in the phototransduction and retinoid cycle pathways. Within these pathways TULP1 collaborates with essential proteins like RPGR and rhodopsin. These collaborations help regulate the transport processes necessary for photoreceptor cell homeostasis contributing to normal visual function and preservation of the retina's structural integrity.

TULP1 mutations associate with retinal-related conditions like retinitis pigmentosa and Leber congenital amaurosis. The connection between TULP1 and these disorders stems from disrupted function of TULP1 leading to impaired transport and eventual photoreceptor degeneration. Additionally a lack of functional interaction between TULP1 and other proteins like rhodopsin contributes significantly to retinal cell damage highlighting TULP1's relevance in hereditary retinal diseases.
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製品の性状

製品の状態

Liquid

補足情報

ab131704 is purified using conventional chromatography techniques

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一般的な情報

機能

Required for normal development of photoreceptor synapses. Required for normal photoreceptor function and for long-term survival of photoreceptor cells. Interacts with cytoskeleton proteins and may play a role in protein transport in photoreceptor cells (By similarity). Binds lipids, especially phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-bisphosphate, phosphatidylserine and phosphatidic acid (in vitro). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages.

配列の類似性

Belongs to the TUB family.

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製品プロトコール

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ターゲットの情報

Required for normal development of photoreceptor synapses. Required for normal photoreceptor function and for long-term survival of photoreceptor cells. Interacts with cytoskeleton proteins and may play a role in protein transport in photoreceptor cells (By similarity). Binds lipids, especially phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-bisphosphate, phosphatidylserine and phosphatidic acid (in vitro). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages.
See full target information TULP1
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