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AB167886

Recombinant Human TUG protein

Recombinant Human TUG protein

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Recombinant Human TUG protein is a Human Full Length protein, in the 1 to 553 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

別名を表示する

ASPL, RCC17, TUG, UBXD9, UBXN9, ASPSCR1, Tether containing UBX domain for GLUT4, Alveolar soft part sarcoma chromosomal region candidate gene 1 protein, Alveolar soft part sarcoma locus, Renal papillary cell carcinoma protein 17, UBX domain-containing protein 9

1 Images
SDS-PAGE - Recombinant Human TUG protein (AB167886)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human TUG protein (AB167886)

15% SDS-PAGE analysis of ab167886 (3µg).

Key facts

精製度

>85% SDS-PAGE

発現系

Escherichia coli

タグ

His tag N-Terminus

アプリケーション

SDS-PAGE

applications

生物活性

No

アクセッション番号

Q9BZE9

アニマルフリー

No

キャリアフリー

No

種

Human

バッファー組成

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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配列情報

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMAAPAGGGGSAVSVLAPNGRRHTVKVTPSTVLLQVLEDTCRRQDFNPCEYDLKFQRSVLDLSLQWRFANLPNNAKLEMVPASRSREGPENMVRIALQLDDGSRLQDSFCSGQTLWELLSHFPQIRECLQHPGGATPVCVYTRDEVTGEAALRGTTLQSLGLTGGSATIRFVMKCYDPVGKTPGSLGSSASAGQAAASAPLPLESGELSRGDLSRPEDADTSGPCCEHTQEKQSTRAPAAAPFVPFSGGGQRLGGPPGPTRPLTSSSAKLPKSLSSPGGPSKPKKSKSGQDPQQEQEQERERDPQQEQERERPVDREPVDREPVVCHPDLEERLQAWPAELPDEFFELTVDDVRRRLAQLKSERKRLEEAPLVTKAFREAQIKEKLERYPKVALRVLFPDRYVLQGFFRPSETVGDLRDFVRSHLGNPELSFYLFITPPKTVLDDHTQTLFQANLFPAALVHLGAEEPAGVYLEPGLLEHAISPSAADVLVARYMSRAAGSPSPLPAPDPAPKSEPAAEEGALVPPEPIPGTAQPVKRSLGKVPKWLKLPASKR","proteinLength":"Full Length","predictedMolecularWeight":"62.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":553,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9BZE9","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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出荷温度及び保存条件

出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
False
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Tether containing a UBX domain for GLUT4 (TUG) also known as ASPSCR1 is a protein that plays a role in cellular trafficking. TUG weighs approximately 67 kDa. It is predominantly expressed in adipose tissue and muscle. TUG acts as an inhibitor that helps regulate the recycling and translocation of the glucose transporter type 4 (GLUT4) by tethering it in the cytoplasm until stimulated by insulin.
Biological function summary

TUG regulates glucose homeostasis and energy balance. It forms a complex with GLUT4-containing vesicles controlling their movement to the plasma membrane in response to insulin stimulation. When insulin is present TUG undergoes proteolytic cleavage releasing GLUT4 so that it can facilitate glucose uptake into cells. This regulation of glucose transport is essential in maintaining normal blood glucose levels.

Pathways

TUG operates within the insulin signaling pathway and glucose transport pathway. By interacting with GLUT4 TUG controls its translocation important for insulin-mediated glucose uptake. Another significant pathway involving TUG is the trafficking of proteins through the Golgi apparatus where TUG might interact with other UBX domain-containing proteins to manage vesicular traffic.

TUG is linked to type 2 diabetes and insulin resistance. Abnormalities in TUG function or expression can disrupt normal GLUT4 trafficking and impair glucose uptake contributing to these metabolic disorders. Furthermore TUG might interact with proteins related to Alzheimer's disease such as those impacting insulin signaling suggesting a potential role in the pathophysiology of neurodegenerative disorders.
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製品の性状

製品の状態

Liquid

補足情報

ab167886 is purified using conventional chromatography techniques.

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一般的な情報

機能

Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface (By similarity). Enhances VCP methylation catalyzed by VCPKMT.

細胞内局在性

Nucleus

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製品プロトコール

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ターゲットの情報

Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface (By similarity). Enhances VCP methylation catalyzed by VCPKMT.
See full target information ASPSCR1
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組合せ製品

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Primary Antibodies

AB131237

Anti-TUG antibody [EPR8615]

RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TUG antibody [EPR8615] (AB131237)

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Recombinant Human TPK1 protein

SDS-PAGE - Recombinant Human TPK1 protein (AB123150)

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