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AB124598

Recombinant Human TRP14 protein (His tag N-Terminus)

Recombinant Human TRP14 protein (His tag N-Terminus)

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Recombinant Human TRP14 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 123 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

別名を表示する

TXNL5, TXNDC17, Thioredoxin domain-containing protein 17, 14 kDa thioredoxin-related protein, Protein 42-9-9, Thioredoxin-like protein 5, TRP14

1 Images
SDS-PAGE - Recombinant Human TRP14 protein (His tag N-Terminus) (AB124598)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human TRP14 protein (His tag N-Terminus) (AB124598)

15% SDS-PAGE showing ab124598 (3µg).

Key facts

精製度

>95% SDS-PAGE

ab124598 is purified using conventional chromatography techniques.

発現系

Escherichia coli

タグ

His tag N-Terminus

アプリケーション

Mass Spec, SDS-PAGE

applications

生物活性

No

アクセッション番号

Q9BRA2

アニマルフリー

No

キャリアフリー

No

種

Human

バッファー組成

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.32% Tris HCl, 0.29% Sodium chloride

storage-buffer

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組合せ製品

Proteins & Peptides

AB226268

Recombinant Human SDHA protein (Tagged)

Mass Spectrometry - Recombinant Human SDHA protein (Tagged) (AB226268)

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Primary Antibodies

AB121725

Anti-TRP14 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRP14 antibody (AB121725)

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Proteins & Peptides

AB106888

Recombinant E. coli cysH protein (His tag N-Terminus)

SDS-PAGE - Recombinant E. coli cysH protein (His tag N-Terminus) (AB106888)

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Proteins & Peptides

AB96771

Recombinant Human UGDH protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human UGDH protein (His tag N-Terminus) (AB96771)

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  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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製品の詳細

Previously labelled as TXNDC17.
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配列情報

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMGSHMARYEEVSVSGFEEFHRAVEQHNGKTIFAYFTGSKDAGGKSWCPDCVQAEPVVREGLKHISEGCVFIYCQVGEKPYWKDPNNDFRKNLKVTAVPTLLKYGTPQKLVESECLQANLVEMLFSED","proteinLength":"Full Length","predictedMolecularWeight":"16.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":123,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9BRA2","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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出荷温度及び保存条件

製品の状態
Liquid
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
False
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

TRP14 also known as thioredoxin-related protein 14 functions as a redox-active protein. It has a molecular mass of approximately 14 kDa. Mechanically TRP14 catalyzes the reduction of disulfide bonds in proteins playing a role in maintaining cellular redox homeostasis. Its action depends on a CXXC motif in its active site which transfers electrons to disulfides. TRP14 expresses in various human tissues with notable levels in the heart and lungs.
Biological function summary

TRP14 impacts the cellular reduction-oxidation state participating in processes of cell growth and defense against oxidative stress. It does not typically form part of larger protein complexes but instead acts independently within the cell to exert its function. Through its catalytic activity TRP14 influences signaling events that dictate cellular response to harmful oxidative conditions.

Pathways

TRP14 integrates into the thioredoxin system which regulates redox-sensitive signaling pathways. These pathways involve proteins such as TRP32 and thioredoxin. The activity of TRP14 also contributes to the oxidative stress response pathway affecting the activation of downstream targets like Nrf2 a transcription factor that mediates antioxidant defense.

TRP14 shows connection to cancer and cardiovascular diseases. Its role in maintaining redox balance can influence tumor progression and cellular transformation processes in cancer. In cardiovascular diseases oxidative stress plays an important role and TRP14 through its interaction with other redox proteins like thioredoxin may modulate associated cellular damage contributing to disease pathology.
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一般的な情報

機能

Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Modulates TNF signaling and NF-kappa-B activation. Has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide.

配列の類似性

Belongs to the thioredoxin family.

翻訳後修飾

The oxidized protein is reduced by TRXR1.

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製品プロトコール

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ターゲットの情報

Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Modulates TNF signaling and NF-kappa-B activation. Has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide.
See full target information TXNDC17
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