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AB153070

Recombinant Human TRK fused gene protein (GST tag N-Terminus)

Recombinant Human TRK fused gene protein (GST tag N-Terminus)

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Recombinant Human TRK fused gene protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 400 aa range, expressed in Wheat germ, suitable for ELISA, WB.

別名を表示する

Protein TFG, TRK-fused gene protein, TFG

1 Images
SDS-PAGE - Recombinant Human TRK fused gene protein (GST tag N-Terminus) (AB153070)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human TRK fused gene protein (GST tag N-Terminus) (AB153070)

ab153070 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

発現系

Wheat germ

タグ

GST tag N-Terminus

アプリケーション

WB, ELISA

applications

生物活性

No

アクセッション番号

Q92734

アニマルフリー

No

キャリアフリー

No

種

Human

バッファー組成

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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配列情報

[{"sequence":"MNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKLTLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDEINKNVMSAFGLTDDQVSGPPSAPAEDRSGTPDSIASSSSAAHPPGVQPQQPPYTGAQTQAGQIEGQMYQQYQQQAGYGAQQPQAPPQQPQQYGIQYSASYSQQTGPQQPQQFQGYGQQPTSQAPAPAFSGQPQQLPAQPPQQYQASNYPAQTYTAQTSQPTNYTVAPASQPGMAPSQPGAYQPRPGFTSLPGSTMTPPPSGPNPYARNRPPFGQGYTQPGPGYR","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":400,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q92734","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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出荷温度及び保存条件

出荷温度
Dry Ice
短期保存温度
-80°C
長期保存温度
-80°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
False
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The TRK fused gene also known as NTRK or tropomyosin receptor kinase encodes for a family of proteins integral to neurotrophin signaling. These proteins weighing approximately 80-90 kilodaltons include isoforms such as TRKA TRKB and TRKC which are products of the NTRK1 NTRK2 and NTRK3 genes respectively. They express mainly in neuronal tissues and certain non-neuronal cells. These proteins possess a diverse range of functions largely due to structural variations derived from gene fusions.
Biological function summary

Neurotrophin signaling pathways involve TRK proteins facilitating neuronal differentiation survival and plasticity. TRK proteins often form part of larger complexes engaged in transmitting signals from the extracellular environment to intracellular pathways. The TRK proteins interact with neurotrophins like NGF BDNF and NT-3 playing essential roles in nervous system function and development. The interaction between TRK receptors and their ligands activates downstream signaling cascades.

Pathways

TRK proteins significantly contribute to the MAPK/ERK and PI3K/Akt pathways. These pathways control cell growth differentiation and survival. Within these pathways TRK proteins interact with partners such as Ras and Akt coordinating a broad range of cellular processes. They ensure proper cellular responses to external stimuli and maintain homeostasis within the cell.

TRK fusion proteins frequently associate with certain cancers including thyroid and lung cancer due to gene fusions leading to overactive signaling. Altered TRK signaling correlates with neurodegenerative diseases as well such as Alzheimer's disease. TRK fusions can affect proteins like ETV6 and LMNA in the context of cancer influencing tumorigenesis and disease progression. Understanding the connections between TRK fusions and these diseases aids the development of target-specific therapies.
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製品の性状

製品の状態

Liquid

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一般的な情報

機能

Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules (PubMed : 23479643, PubMed : 27813252). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed : 21478858).

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製品プロトコール

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ターゲットの情報

Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules (PubMed : 23479643, PubMed : 27813252). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed : 21478858).
See full target information Protein TFG
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組合せ製品

Primary Antibodies

AB156866

Anti-TRK fused gene antibody [EPR8766]

RabMAb|Recombinant|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-TRK fused gene antibody [EPR8766] (AB156866)

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Cell Lines & Lysates

AB265841

Human TFG (TRK fused gene) knockout HeLa cell line

Advanced Validation

Western blot - Human TFG (TRK fused gene) knockout HeLa cell line (AB265841)

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Cell Lines & Lysates

AB257738

Human TFG (TRK fused gene) knockout HeLa cell lysate

Western blot - Human TFG (TRK fused gene) knockout HeLa cell lysate (AB257738)

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Primary Antibodies

AB236632

Anti-HA tag antibody [EPR22819-101]

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HA tag antibody [EPR22819-101] (AB236632)

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