AB165536

Recombinant Human TMED6 protein (GST tag N-Terminus)

Name: Recombinant Human TMED6 protein (ab165536) | Abcam
Brand: Abcam Limited
SKU: AB165536
Price: 118000 JPY
Availability: InStock

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(1 Publication)

Recombinant Human TMED6 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 240 aa range, expressed in Wheat germ, suitable for ELISA, WB.

別名を表示する

UNQ9146/PRO34237, TMED6, Transmembrane emp24 domain-containing protein 6, p24 family protein gamma-5, p24gamma5

1 Images

SDS-PAGE - Recombinant Human TMED6 protein (GST tag N-Terminus) (AB165536)

SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human TMED6 protein (GST tag N-Terminus) (AB165536)

ab165536 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

発現系

Wheat germ

アプリケーション

ELISA, WB

applications

生物活性

アクセッション番号

Q8WW62

アニマルフリー

キャリアフリー

種

Human

バッファー組成

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

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配列情報

[{"sequence":"MSPLLFGAGLVVLNLVTSARSQKTEPLSGSGDQPLFRGADRYDFAIMIPPGGTECFWQFAHQTGYFYFSCEVQRTVGMSHDRHVAATAHNPQGFLIDTSQGVRGQINFSTQETGFYQLCLSNQHNHFGSVQVYLNFGVFYEGPETDHKQKERKQLNDTLDAIEDGTQKVQNNIFHMWRYYNFARMRKMADFFLIQSNYNYVNWWSTAQSLVIILSGILQLYFLKRLFNVPTTTDTKKPRC","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":240,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q8WW62","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]

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出荷温度及び保存条件

出荷温度

Dry Ice

短期保存温度

-80°C

長期保存温度

-80°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

False

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

TMED6 also known as Transmembrane Emp24 domain-containing protein 6 plays a role in cellular transport processes. It is a protein with a mass of about 29 kDa. TMED6 is involved in the trafficking of proteins between the endoplasmic reticulum and the Golgi apparatus. Expression of TMED6 is seen in various tissues including liver heart and brain highlighting its broad relevance in different physiological processes.

Biological function summary

TMED6 participates in maintaining the integrity of the secretory pathway. It is part of the p24 family which contributes to the coat protein complex (COPI and COPII) vesicles responsible for shuttling proteins between cellular compartments. This role facilitates the correct sorting and modification of proteins ensuring they reach their intended cellular destinations.

Pathways

TMED6 has an integral part in the secretory pathway and the vesicular transport process. It interacts with proteins like COPI and COPII which are important for vesicle budding from the endoplasmic reticulum. The secretory pathway is essential for protein processing and trafficking affecting how cells respond to various stimuli and maintain homeostasis.

Researchers have investigated TMED6's connection to conditions such as Alzheimer's disease and cardiovascular issues. Alzheimer's disease shows altered endoplasmic reticulum and Golgi function where TMED6's interactions with proteins such as gamma-secretase suggest a potential role in pathogenesis. Additionally cardiovascular disorders involve disruptions in protein transport pathways wherein TMED6's function in vesicular traffic could influence disease states.

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製品の性状

製品の状態

Liquid

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一般的な情報

配列の類似性

Belongs to the EMP24/GP25L family.

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製品プロトコール

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

See full target information TMED6

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 13:1815 PubMed35383192

2022

RNA aptamers specific for transmembrane p24 trafficking protein 6 and Clusterin for the targeted delivery of imaging reagents and RNA therapeutics to human β cells.

Applications

Unspecified application

Species

Unspecified reactive species

Dimitri Van Simaeys,Adriana De La Fuente,Serena Zilio,Alessia Zoso,Victoria Kuznetsova,Oscar Alcazar,Peter Buchwald,Andrea Grilli,Jimmy Caroli,Silvio Bicciato,Paolo Serafini

View all publications

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Abcam product promise

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Recombinant Human TMED6 protein (GST tag N-Terminus)