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Recombinant Human TGF beta 1 protein (ab82991)

Submit a review Q&A (1)
SDS-PAGE - Recombinant Human TGF beta 1 protein (ab82991)

    Key features and details

    • Expression system: Escherichia coli
    • Purity: > 95% SDS-PAGE
    • Suitable for: SDS-PAGE

    製品の詳細

    特性

    Our Abpromise guarantee covers the use of ab82991 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • アプリケーション

      SDS-PAGE

    • 製品の状態

      Liquid
    • Concentration information loading...

    前処理および保存

    • 保存方法および安定性

      Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.

      pH: 4.80
      Constituents: 50% Glycerol (glycerin, glycerine), 0.3% Sodium acetate trihydrate

    関連情報

    • 別名

      • Cartilage-inducing factor
      • CED
      • Differentiation inhibiting factor
      • DPD1
      • LAP
      • Latency-associated peptide
      • Prepro transforming growth factor beta 1
      • TGF beta
      • TGF beta 1
      • TGF beta 1 protein
      • TGF-beta 1 protein
      • TGF-beta-1
      • TGF-beta-5
      • TGF-beta1
      • TGFB
      • Tgfb-1
      • tgfb1
      • TGFB1_HUMAN
      • TGFbeta
      • TGFbeta1
      • Transforming Growth Factor b1
      • Transforming Growth Factor beta 1
      • Transforming growth factor beta 1a
      • transforming growth factor beta-1
      • transforming growth factor, beta 1
      • Transforming Growth Factor-ß1
      see all

    • 機能

      Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts.

    • 組織特異性

      Highly expressed in bone. Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA). Co-localizes with ASPN in chondrocytes within OA lesions of articular cartilage.

    • 関連疾患

      Defects in TGFB1 are the cause of Camurati-Engelmann disease (CE) [MIM:131300]; also known as progressive diaphyseal dysplasia 1 (DPD1). CE is an autosomal dominant disorder characterized by hyperostosis and sclerosis of the diaphyses of long bones. The disease typically presents in early childhood with pain, muscular weakness and waddling gait, and in some cases other features such as exophthalmos, facial paralysis, hearing difficulties and loss of vision.

    • 配列類似性

      Belongs to the TGF-beta family.

    • 翻訳後修飾

      Glycosylated.
      The precursor is cleaved into mature TGF-beta-1 and LAP, which remains non-covalently linked to mature TGF-beta-1 rendering it inactive.

    • 細胞内局在

      Secreted > extracellular space > extracellular matrix.
    • Information by UniProt

    画像

    • SDS-PAGE - Recombinant Human TGF beta 1 protein (ab82991)
      SDS-PAGE - Recombinant Human TGF beta 1 protein (ab82991)
      SDS-PAGE showing ab82991.

    プロトコール

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    参考文献 (0)

    ab82991 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab82991 は論文での使用が確認できていません。

    レビューと Q&A

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    レビューを送る 質問を送る

    Question

    Latent inactive form of TGF beta.

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    Answer

    Thank you for contacting us.

    I have now received an answer from lab. The protein ab82991 can be used in ELISA but the biological activity of this protein has not been tested so we unfortunately will not be able to confirm whether the protein is active or not.

    I am sorry we are unable to provide more definite answer due to lack of data. However in order help you in research we are happy to provide you Abreview discount for testing this protein's activity. The discount code will be worth the price you pay for ab82991. Full terms and conditions can found by clicking below link;

    https://www.abcam.com/index.html?pageconfig=resource&rid=11998&viapagetrap=collaborationdiscount

    The protein ab82992 is for WB only because it contains LDS; it may not be suitable for your purpose.

    We unfortunately do not have any other product matching your request.

    I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

    Use our products? Submit an Abreview. Earn rewards!
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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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