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AB167855

Recombinant Human Tef protein

Recombinant Human Tef protein

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Recombinant Human Tef protein is a Human Full Length protein, in the 1 to 303 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.

別名を表示する

KIAA1655, TEF, Thyrotroph embryonic factor

1 Images
SDS-PAGE - Recombinant Human Tef protein (AB167855)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Tef protein (AB167855)

15% SDS-PAGE analysis of ab167855 (3µg). Molecular size on SDS-PAGE appears higher.

Key facts

精製度

>85% SDS-PAGE

発現系

Escherichia coli

タグ

His tag N-Terminus

アプリケーション

SDS-PAGE, Mass Spec

applications

生物活性

No

アクセッション番号

Q10587

アニマルフリー

No

キャリアフリー

No

種

Human

バッファー組成

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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配列情報

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMSDAGGGKKPPVDPQAGPGPGPGRAAGERGLSGSFPLVLKKLMENPPREARLDKEKGKEKLEEDEAAAASTMAVSASLMPPIWDKTIPYDGESFHLEYMDLDEFLLENGIPASPTHLAHNLLLPVAELEGKESASSSTASPPSSSTAIFQPSETVSSTESSLEKERETPSPIDPNCVEVDVNFNPDPADLVLSSVPGGELFNPRKHKFAEEDLKPQPMIKKAKKVFVPDEQKDEKYWTRRKKNNVAAKRSRDARRLKENQITIRAAFLEKENTALRTEVAELRKEVGKCKTIVSKYETKYGPL","proteinLength":"Full Length","predictedMolecularWeight":"35.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":303,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q10587","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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出荷温度及び保存条件

出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
False
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The 'Tef' protein also known as thyrotroph embryonic factor plays a mechanistic role as a transcription factor. It weighs approximately 31 kilodaltons. Tef is expressed in several tissues but most prominently within the liver as well as in the heart. This protein belongs to the PAR bZip (proline and acidic amino acid-rich basic leucine zipper) family which is recognized for its ability to bind to DNA sequences to regulate transcriptional activity.
Biological function summary

The 'Tef' protein engages in important cellular processes that control circadian rhythms. It operates in a complex with other transcription factors which include DBP and HLF. These factors coordinate to regulate the expression of genes that follow a circadian pattern. The ability of Tef protein to influence gene expression at different times of the day allows it to maintain the internal biological clock's precision affecting metabolic and sleep-related activities.

Pathways

There is considerable involvement of 'Tef' in the regulation of the circadian rhythm pathway. Additionally Tef integrates with the glucose metabolism pathway influencing gene expression tied to metabolic cycles. Proteins such as CLOCK and BMAL1 are related through these pathways orchestrating gene networks critical to diurnal variations and energy homeostasis.

'Tef' is linked to metabolic syndrome and sleep disorders. Its influence on circadian rhythms makes Tef an important protein in diseases related to the disruption of these cycles. Anomalies in its pathways may connect with other proteins like PER1 and CRY which factor into the development of symptoms associated with metabolic imbalance and disordered sleep patterns.
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製品の性状

製品の状態

Liquid

補足情報

ab167855 was purified using conventional chromatography techniques.

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一般的な情報

機能

Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5'-[TC][AG][AG]TTA[TC][AG]-3'.

配列の類似性

Belongs to the bZIP family. PAR subfamily.

細胞内局在性

Nucleus

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製品プロトコール

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ターゲットの情報

Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5'-[TC][AG][AG]TTA[TC][AG]-3'.
See full target information TEF
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