AB109961

Recombinant Human SULT1A2 protein (His tag N-Terminus)

Name: Recombinant Human SULT1A2 protein (ab109961) | Abcam
Brand: Abcam Limited
SKU: AB109961
Price: 88000 JPY
Availability: InStock

Be the first to review this product! Submit a review

(0 Publication)

Recombinant Human SULT1A2 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 295 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

別名を表示する

STP2, SULT1A2, Sulfotransferase 1A2, ST1A2, Aryl sulfotransferase 2, Phenol sulfotransferase 2, Phenol-sulfating phenol sulfotransferase 2, P-PST 2

1 Images

SDS-PAGE - Recombinant Human SULT1A2 protein (His tag N-Terminus) (AB109961)

SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human SULT1A2 protein (His tag N-Terminus) (AB109961)

15% SDS-PAGE analysis of 3μg ab109961.

Key facts

精製度

>95% SDS-PAGE

ab109961 was purified using conventional chromatography techniques.

発現系

Escherichia coli

アプリケーション

Mass Spec, SDS-PAGE

applications

生物活性

アクセッション番号

P50226

アニマルフリー

キャリアフリー

種

Human

バッファー組成

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.316% Tris HCl, 0.058% Sodium chloride, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

style

left-column

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

style

left-column

style

left-column

配列情報

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMELIQDISRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKVPGIPSGMETLKNTPAPRLLKTHLPLALLPQTLLDQKVKVVYVARNAKDVAVSYYHFYHMAKVYPHPGTWESFLEKFMAGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKREIQKILEFVGRSLPEETVDLMVEHTSFKEMKKNPMTNYTTVRREFMDHSISPFMRKGMAGDWKTTFTVAQNERFDADYAEKMAGCSLSFRSEL","proteinLength":"Full Length","predictedMolecularWeight":"36.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":295,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P50226","tags":[{"tag":"His","terminus":"N-Terminus"}]}]

style

left-column

出荷温度及び保存条件

製品の状態

Liquid

出荷温度

Blue Ice

短期保存温度

-20°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

False

style

left-column

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

SULT1A2 also known as Sulfotransferase Family 1A Member 2 is an enzyme involved in the sulfonation pathway. This enzyme has a molecular weight of approximately 34 kDa and is expressed mainly in the liver as well as other tissues like the intestines and lungs. Mechanically SULT1A2 functions by transferring sulfate groups to various substrates including hormones drugs and xenobiotic compounds. This enzymatic activity plays an important role in increasing the solubility of these molecules facilitating their excretion from the body.

Biological function summary

The sulfonation activity of SULT1A2 contributes to the regulation and metabolism of hormones and drugs. It is not part of a larger complex but works independently to modulate hormone activity and detoxify xenobiotics. This enzyme's ability to modify the biochemical properties of its substrates is essential in cellular regulation and homeostasis impacting physiological processes in humans.

Pathways

The activity of SULT1A2 is involved in the metabolism and detoxification pathways. It closely interacts with other phase II detoxification enzymes such as those in the UDP-glucuronosyltransferase family. Through these pathways SULT1A2 helps transform hydrophobic compounds into more hydrophilic forms aiding in their elimination from the organism. The enzyme's role in hormone homeostasis connects it to pathways involving hormone regulation and action.

SULT1A2 has links to certain cancers and drug metabolism disorders. In cancers altered expression levels of SULT1A2 may affect the balance of hormones potentially contributing to oncogenesis. It has also been noted in disorders of drug metabolism where malfunction of SULT1A2 can impact the efficacy and toxicity of administered medications. The enzyme interacts with cytochrome P450 family proteins which play roles in the metabolic pathways of both drugs and endogenous compounds.

style

left-column

一般的な情報

機能

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Is also responsible for the sulfonation and activation of minoxidil. Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.

配列の類似性

Belongs to the sulfotransferase 1 family.

style

left-column

製品プロトコール

Visit the General protocols
Visit the Troubleshooting

style

left-column

ターゲットの情報

See full target information SULT1A2

style

left-column

style

left-column

style

right-column

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Recombinant Human SULT1A2 protein (His tag N-Terminus)