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AB126657

Recombinant Human STAP-1 protein (His tag N-Terminus)

Recombinant Human STAP-1 protein (His tag N-Terminus)

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Recombinant Human STAP-1 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 295 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

別名を表示する

BRDG1, STAP1, Signal-transducing adaptor protein 1, STAP-1, BCR downstream-signaling protein 1, Docking protein BRDG1, Stem cell adaptor protein 1

1 Images
SDS-PAGE - Recombinant Human STAP-1 protein (His tag N-Terminus) (AB126657)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human STAP-1 protein (His tag N-Terminus) (AB126657)

ab126657 at 3 μg analysed by SDS PAGE.

Key facts

精製度

>95% SDS-PAGE

発現系

Escherichia coli

タグ

His tag N-Terminus

アプリケーション

Mass Spec, SDS-PAGE

applications

生物活性

No

アクセッション番号

Q9ULZ2

アニマルフリー

No

キャリアフリー

No

種

Human

バッファー組成

pH: 8 Constituents: 30% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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製品の詳細

Previously labelled as BRDG 1.
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配列情報

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSHMMAKKPPKPAPRRIFQERLKITALPLYFEGFLLIKRSGYREYEHYWTELRGTTLFFYTDKKSIIYVDKLDIVDLTCLTEQNSTEKNCAKFTLVLPKEEVQLKTENTESGEEWRGFILTVTELSVPQNVSLLPGQVIKLHEVLEREKKRRIETEQSTSVEKEKEPTEDYVDVLNPMPACFYTVSRKEATEMLQKNPSLGNMILRPGSDSRNYSITIRQEIDIPRIKHYKVMSVGQNYTIELEKPVTLPNLFSVIDYFVKETRGNLRPFICSTDENTGQEPSMEGRSEKLKKNPHIA","proteinLength":"Full Length","predictedMolecularWeight":"36.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":295,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9ULZ2","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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出荷温度及び保存条件

出荷温度
Blue Ice
短期保存温度
-20°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
False
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

STAP-1 also known as Signal Transducing Adaptor Protein-1 has a mass of approximately 31 kDa. Mechanically STAP-1 functions as an adaptor protein that engages in signaling pathways. This protein interacts with several signaling molecules to modulate cellular responses. STAP-1 shows expression in immune cells especially in B-cells and T-cells indicating its role in immune system regulation.
Biological function summary

STAP-1 modulates the signaling pathways that govern cell growth and differentiation. It participates in forming complexes with other proteins to transduce signals from the cell surface to the nucleus. STAP-1's ability to bind phosphotyrosine residues allows it to act as a scaffold for other signaling molecules in immune responses. Its interaction with other pathway proteins suggests its role in cellular processes beyond immunity influencing various cellular outcomes.

Pathways

STAP-1 integrates into the JAK-STAT signaling pathway and the PI3K-Akt pathway. These pathways play a central role in regulating immune cell function and proliferation. STAP-1 associates with proteins such as STAT3 and PI3K linking it to important signaling cascades that control gene expression and cell survival. In the JAK-STAT pathway STAP-1's interaction with STAT proteins emphasizes its involvement in transmitting extracellular cues to the nucleus.

STAP-1 connects to autoimmune diseases and certain cancers. Abnormal STAP-1 expression or function can impact immune system regulation potentially contributing to conditions such as lupus or leukemia. STAP-1 associates with proteins like BCR-ABL in the context of leukemia linking it to malignancy pathways. Investigation into STAP-1's role in these disorders provides insights into its potential as a therapeutic target.
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製品の性状

製品の状態

Liquid

補足情報

ab126657 is purified using conventional chromatography techniques

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一般的な情報

機能

In BCR signaling, appears to function as a docking protein acting downstream of TEC and participates in a positive feedback loop by increasing the activity of TEC.

翻訳後修飾

Phosphorylated on tyrosine by TEC. Phosphorylated on tyrosine by KIT (By similarity).

細胞内局在性

Nucleus

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製品プロトコール

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ターゲットの情報

In BCR signaling, appears to function as a docking protein acting downstream of TEC and participates in a positive feedback loop by increasing the activity of TEC.
See full target information STAP1
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