Recombinant Human SRD5A2 protein (ab114946)
Key features and details
- Expression system: Wheat germ
- Tags: GST tag N-Terminus
- Suitable for: ELISA, SDS-PAGE, WB
製品の詳細
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製品名
Recombinant Human SRD5A2 protein -
発現系
Wheat germ -
アクセッション番号
-
タンパク質長
Protein fragment -
Animal free
No -
由来
Recombinant -
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生物種
Human -
配列
AKPSGYGKHTESLKPAATRLPARAAWFLQELPSFAVPA -
予測される分子量
30 kDa including tags -
領域
28 to 65 -
タグ
GST tag N-Terminus
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特性
Our Abpromise guarantee covers the use of ab114946 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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アプリケーション
ELISA
SDS-PAGE
Western blot
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製品の状態
Liquid -
Concentration information loading...
前処理および保存
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保存方法および安定性
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00
Constituents: 0.3% Glutathione, 0.79% Tris HCl
関連情報
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別名
- 3 oxo 5 alpha steroid 4 dehydrogenase 2
- 3-oxo-5-alpha-steroid 4-dehydrogenase 2
- 5 alpha SR2
see all -
機能
Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology. -
組織特異性
Expressed in high levels in the prostate and many other androgen-sensitive tissues. -
関連疾患
Defects in SRD5A2 are the cause of pseudovaginal perineoscrotal hypospadias (PPSH) [MIM:264600]. A form of male pseudohermaphroditism in which 46,XY males show ambiguous genitalia at birth, including perineal hypospadias and a blind perineal pouch, and develop masculinization at puberty. The name of the disorder stems from the finding of a blind-ending perineal opening resembling a vagina and a severely hypospadiac penis with the urethra opening onto the perineum. -
配列類似性
Belongs to the steroid 5-alpha reductase family. -
細胞内局在
Microsome membrane. Endoplasmic reticulum membrane. - Information by UniProt
画像
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SDS-PAGE - Recombinant Human SRD5A2 protein (ab114946)12.5% SDS-PAGE showing ab114946 at approximately 29.81kDa.
Stained with Coomassie Blue.
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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Datasheet download
参考文献 (0)
ab114946 は論文での使用が確認できていません。
