AB169843

Recombinant human SOX2 protein

Name: Recombinant human SOX2 protein (ab169843) | Abcam
Brand: Abcam Limited
SKU: AB169843
Price: 69000 JPY
Availability: InStock

Be the first to review this product! Submit a review

(4 Publications)

Recombinant human SOX2 protein is a Human Full Length protein, in the 1 to 317 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, FuncS.

別名を表示する

Transcription factor SOX-2, SOX2

Key facts

精製度

>90% SDS-PAGE

発現系

Escherichia coli

アプリケーション

FuncS, SDS-PAGE

applications

生物活性

Yes

生物学的活性

Active

アクセッション番号

P48431

アニマルフリー

キャリアフリー

種

Human

バッファー組成

pH: 7.5 Constituents: EDTA, Glycerol (glycerin, glycerine), Potassium chloride, Sodium chloride, 0.24% Tris

storage-buffer

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

style

left-column

製品の詳細

The in vitro function was tested using specific DNA binding assays. 11R proteins were reported to successfully generate induced pluripotent stem (iPS) cells from OG2 MEFs.

style

left-column

配列情報

[{"sequence":"MYNMMETELKPPGPQQTSGGGGGNSTAAAAGGNQKNSPDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTLPGGLLAPGGNSMASGVGVGAGLGAGVNQRMDSYAHMNGWSNGSYSMMQDQLGYPQHPGLNAHGAAQMQPMHRYDVSALQYNSMTSSQTYMNGSPTYSMSYSQQGTPGMALGSMGSVVKSEASSSPPVVTSSSHSRAPCQAGDLRDMISMYLPGAEVPEPAAPSRLHMSQHYQSGPVPGTAINGTLPLSHMESGGGGSPGRRRRRRRRRRR","proteinLength":"Full Length","predictedMolecularWeight":"36.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":317,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P48431","tags":[]}]

style

left-column

出荷温度及び保存条件

出荷温度

Blue Ice

短期保存温度

-20°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

True

style

left-column

style

left-column

製品の性状

製品の状態

Liquid

style

left-column

一般的な情報

機能

The protein expressed by the gene SOX2 is critical for early embryogenesis and for the pluripotency of embryonic stem cells (PubMed : 18035408). This supplementary information is collated from multiple sources and compiled automatically.

翻訳後修飾

Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation.. Methylation at Lys-42 and Lys-117 is necessary for the regulation of SOX2 proteasomal degradation.. Ubiquitinated by WWP2, leading to proteasomal degradation.

細胞内局在性

Nucleus

style

left-column

製品プロトコール

Visit the General protocols
Visit the Troubleshooting

style

left-column

ターゲットの情報

See full target information SOX2

style

left-column

文献 (4)

Recent publications for all applications. Explore the full list and refine your search

PLoS pathogens 18:e1010887 PubMed36223427

2022

Inhibitors of ApiAP2 protein DNA binding exhibit multistage activity against Plasmodium parasites.

Applications

Unspecified application

Species

Unspecified reactive species

Timothy James Russell,Erandi K De Silva,Valerie M Crowley,Kathryn Shaw-Saliba,Namita Dube,Gabrielle Josling,Charisse Flerida A Pasaje,Irene Kouskoumvekaki,Gianni Panagiotou,Jacquin C Niles,Marcelo Jacobs-Lorena,C Denise Okafor,Francisco-Javier Gamo,Manuel Llinás

Cell reports 39:110919 PubMed35675767

2022

Stub1 maintains proteostasis of master transcription factors in embryonic stem cells.

Applications

Unspecified application

Species

Unspecified reactive species

Md Mahfuz Al Mamun,Muhammad Riaz Khan,Yifu Zhu,Yuwei Zhang,Shuai Zhou,Ran Xu,Ihtisham Bukhari,Rick F Thorne,Jinming Li,Xu Dong Zhang,Guangzhi Liu,Song Chen,Mian Wu,Xiaoyuan Song

Nature communications 12:3337 PubMed34099689

2021

High throughput screening identifies SOX2 as a super pioneer factor that inhibits DNA methylation maintenance at its binding sites.

Applications

Unspecified application

Species

Unspecified reactive species

Ludovica Vanzan,Hadrien Soldati,Victor Ythier,Santosh Anand,Simon M G Braun,Nicole Francis,Rabih Murr

Molecular cell 65:589-603.e9 PubMed28212747

2017

Catalytic-Independent Functions of PARP-1 Determine Sox2 Pioneer Activity at Intractable Genomic Loci.

Applications

Unspecified application

Species

Unspecified reactive species

Ziying Liu,W Lee Kraus

View all publications

style

left-column

style

left-column

style

right-column

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Recombinant human SOX2 protein