Recombinant Human SOD2/MnSOD protein (ab84639)
Key features and details
- Expression system: Escherichia coli
- Purity: > 90% Densitometry
- Tags: GST tag N-Terminus
- Suitable for: WB, SDS-PAGE
製品の詳細
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製品名
Recombinant Human SOD2/MnSOD protein
SOD2/MnSOD タンパク質・ペプチド 製品一覧 -
精製度
> 90 % Densitometry. -
発現系
Escherichia coli -
タンパク質長
Full length protein -
Animal free
No -
由来
Recombinant -
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生物種
Human -
領域
1 to 222 -
タグ
GST tag N-Terminus
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関連製品
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Related Products
特性
Our Abpromise guarantee covers the use of ab84639 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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アプリケーション
Western blot
SDS-PAGE
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製品の状態
Liquid -
Concentration information loading...
前処理および保存
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保存方法および安定性
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 7.50
Constituents: 0.00174% PMSF, 0.00385% DTT, 0.79% Tris HCl, 25% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
関連情報
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別名
- Indophenoloxidase B
- IPO B
- IPOB
see all -
機能
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. -
関連疾患
Genetic variation in SOD2 is associated with susceptibility to microvascular complications of diabetes type 6 (MVCD6) [MIM:612634]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. -
配列類似性
Belongs to the iron/manganese superoxide dismutase family. -
翻訳後修飾
Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity. -
細胞内局在
Mitochondrion matrix. - Information by UniProt
画像
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SDS-PAGE - Recombinant Human SOD2/MnSOD protein (ab84639)
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (1)
ab84639 は 1 報の論文で使用されています。
- Zemanovic S et al. Dynamic Phosphorylation of the C Terminus of Hsp70 Regulates the Mitochondrial Import of SOD2 and Redox Balance. Cell Rep 25:2605-2616.e7 (2018). PubMed: 30485823