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AB160261

Recombinant Human SGCE/ESG protein (GST tag N-Terminus)

Recombinant Human SGCE/ESG protein (GST tag N-Terminus)

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Recombinant Human SGCE/ESG protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 437 aa range, expressed in Wheat germ, suitable for ELISA, WB.

別名を表示する

ESG, UNQ433/PRO840, SGCE, Epsilon-sarcoglycan, Epsilon-SG

1 Images
SDS-PAGE - Recombinant Human SGCE/ESG protein (GST tag N-Terminus) (AB160261)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human SGCE/ESG protein (GST tag N-Terminus) (AB160261)

ab160261 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

発現系

Wheat germ

タグ

GST tag N-Terminus

アプリケーション

ELISA, WB

applications

生物活性

No

アクセッション番号

O43556

アニマルフリー

No

キャリアフリー

No

種

Human

バッファー組成

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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製品の詳細

This product was previously labelled as SGCE.
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配列情報

[{"linker":null,"sequence":"MQLPRWWELGDPCAWTGQGRGTRRMSPATTGTFLLTVYSIFSKVHSDRNVYPSAGVLFVHVLEREYFKGEFPPYPKPGEISNDPITFNTNLMGYPDRPGWLRYIQRTPYSDGVLYGSPTAENVGKPTIIEITAYNRRTFETARHNLIINIMSAEDFPLPYQAEFFIKNMNVEEMLASEVLGDFLGAVKNVWQPERLNAINITSALDRGGRVPLPINDLKEGVYVMVGADVPFSSCLREVENPQNQLRCSQEMEPVITCDKKFRTQFYIDWCKISLVDKTKQVSTYQEVIRGEGILPDGGEYKPPSDSLKSRDYYTDFLITLAVPSAVALVLFLILAYIMCCRREGVEKRNMQTPDIQLVHHSAIQKSTKELRDMSKNREIAWPLSTLPVFHPVTGEIIPPLHTDNYDSTNMPLMQTQQNLPHQTQIPQQQTTGKWYP","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":437,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"O43556","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Proprietary technique
出荷温度
Dry Ice
短期保存温度
-80°C
長期保存温度
-80°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
False
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

SGCE/ESG also known as epsilon-sarcoglycan is a protein that is important in forming components of the sarcoglycan complex. The SGCE/ESG protein has a mass of approximately 48 kDa. It is mainly expressed in skeletal and cardiac muscle tissues. Its localization in these muscles suggests an integral role in their structural stability and function.
Biological function summary

The SGCE/ESG protein contributes significantly to the integrity of the dystrophin-glycoprotein complex (DGC). This complex is essential for maintaining the linkage between the cytoskeleton and the extracellular matrix providing mechanical stability to muscle cells during contraction and relaxation. SGCE/ESG is an essential component contributing to the structural organization and proper functioning of muscle fibers.

Pathways

SGCE/ESG is notably involved in the adhesion and signaling pathways within muscle cells. It plays a significant role in the dystroglycan and sarcoglycan complexes. These complexes interact with other proteins like dystrophin and beta-dystroglycan linking the extracellular matrix to the cytoskeleton and mediating signal transduction required for muscle function and repair.

SGCE/ESG mutations are associated with myoclonus-dystonia syndrome a neurological condition that affects movement and posture. The protein's dysfunction disrupts normal communication between muscle cells leading to symptoms characteristic of this disorder. Additionally SGCE/ESG has connections to limb-girdle muscular dystrophy where it interacts with sarcoglycan proteins that when mutated lead to muscle weakness and degeneration.
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一般的な情報

機能

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

配列の類似性

Belongs to the sarcoglycan alpha/epsilon family.

翻訳後修飾

N-glycosylated.. Ubiquitinated, leading to its degradation by the proteasome.

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製品プロトコール

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ターゲットの情報

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
See full target information SGCE
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