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AB151645

Recombinant Human Serum Amyloid P/SAP protein

Recombinant Human Serum Amyloid P/SAP protein

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Recombinant Human Serum Amyloid P/SAP protein is a Human Full Length protein, in the 20 to 223 aa range, expressed in Mammalian, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, HPLC.

別名を表示する

PTX2, APCS, Serum amyloid P-component, SAP, 9.5S alpha-1-glycoprotein

Key facts

精製度

>95% SDS-PAGE

Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.

エンドトキシンレベル

< 1 EU/µg

発現系

Mammalian

タグ

His tag C-Terminus

アプリケーション

SDS-PAGE, HPLC

applications

生物活性

No

アクセッション番号

P02743

アニマルフリー

No

キャリアフリー

No

種

Human

再構成

Reconstitute in PBS

バッファー組成

pH: 7.2 Constituents: 99% Phosphate Buffer, 0.88% Sodium chloride

storage-buffer

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組合せ製品

Reagents, Controls & Accessories

AB116029

Prestained Protein Ladder - Extra broad molecular weight (5 - 245 kDa)

SDS-PAGE - Prestained Protein Ladder - Extra broad molecular weight (5 - 245 kDa) (AB116029)

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Proteins & Peptides

AB283455

Recombinant Human Pentraxin 3/PTX3 protein

Mass Spectrometry - Recombinant Human Pentraxin 3/PTX3 protein (AB283455)

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Proteins & Peptides

AB281801

Recombinant human IL-11 protein (Active)

Premium Bioactive

Mass Spectrometry - Recombinant human IL-11 protein (Active) (AB281801)

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Proteins & Peptides

AB316466

Recombinant Human S100A12/CGRP Protein Standard (His tag)

Sandwich ELISA - Recombinant Human S100A12/CGRP Protein Standard (His tag) (AB316466)

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Proteins & Peptides

AB316604

Recombinant Mouse Calprotectin Protein Standard (His tag)

Sandwich ELISA - Recombinant Mouse Calprotectin Protein Standard (His tag) (AB316604)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "HPLC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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製品の詳細

ab151645 was produced by transfected Human cells.Previously labelled as Serum Amyloid P.
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配列情報

[{"linker":null,"sequence":"HTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWVDHHHHHH","proteinLength":"Full Length","predictedMolecularWeight":"23.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":223,"aminoAcidStart":20,"nature":"Recombinant","expressionSystem":"Mammalian","accessionNumber":"P02743","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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出荷温度及び保存条件

製品の状態
Lyophilized
出荷温度
Blue Ice
短期保存温度
-20°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
False
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Serum Amyloid P component also known as SAP P-SAP or APCS protein is a pentraxin family member. It has a molecular mass of approximately 25 kDa. SAP expresses mainly in the liver and circulates in blood plasma. The protein consists of five identical subunits which form a homopentameric structure. This structure enables SAP to bind to amyloid fibrils a defining mechanical action of this protein.
Biological function summary

SAP plays a role in the immune system by recognizing damaged cells and pathogens. It acts as an opsonin marking these cellular targets for phagocytosis. As part of a complex SAP stabilizes extracellular matrix and amyloid deposits. It binds specifically to amyloid fibrils found in various tissues potentially facilitating their removal by immune cells. The protein's binding actions are important for its role in maintaining tissue and fluid homeostasis.

Pathways

SAP is actively involved in the innate immune response and amyloidogenic pathways. It interacts with the complement system to enhance the clearance of cell debris and amyloid fibrils. The complement system is an important component of innate immunity where SAP can engage with complement proteins like C1q. This interaction suggests that SAP plays roles in modulating both inflammation and tissue repair processes.

SAP has significant connections. SAP is related to systemic amyloidosis where it binds to amyloid deposits affecting multiple organs. Moreover SAP has been implicated in Alzheimer's disease due to its interaction with beta-amyloid protein plaques. In these disorders the involvement of SAP aids researchers in understanding the pathological mechanisms and could open avenues for targeted therapies aimed at modulating SAP functions.
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一般的な情報

機能

Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.

配列の類似性

Belongs to the pentraxin family.

翻訳後修飾

N-glycosylated with a complex biantennary oligosaccharide chain with a sialic acid at the end (disialo-SAP). Monosialo-SAP as well as asioalo-SAP are also detected (PubMed:15174148).

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製品プロトコール

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ターゲットの情報

Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.
See full target information APCS
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