AB153267

Recombinant Human SERBP1 protein

Name: Recombinant Human SERBP1 protein (ab153267) | Abcam
Brand: Abcam Limited
SKU: AB153267
Price: 118000 JPY
Availability: InStock

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Recombinant Human SERBP1 protein is a Human Full Length protein, in the 1 to 402 aa range, expressed in Wheat germ, suitable for ELISA, WB.

別名を表示する

PAIRBP1, CGI-55, SERBP1, SERPINE1 mRNA-binding protein 1, PAI1 RNA-binding protein 1, Plasminogen activator inhibitor 1 RNA-binding protein, PAI-RBP1

1 Images

SDS-PAGE - Recombinant Human SERBP1 protein (AB153267)

SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human SERBP1 protein (AB153267)

ab153267 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

発現系

Wheat germ

アプリケーション

WB, ELISA

applications

生物活性

アクセッション番号

Q8NC51

アニマルフリー

キャリアフリー

種

Human

バッファー組成

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

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配列情報

[{"sequence":"MPGHLQEGFGCVVTNRFDQLFDDESDPFEVLKAAENKKKEAGGGGVGGPGAKSAAQAAAQTNSNAAGKQLRKESQKDRKNPLPPSVGVVDKKEETQPPVALKKEGIRRVGRRPDQQLQGEGKIIDRRPERRPPRERRFEKPLEEKGEGGEFSVDRPIIDRPIRGRGGLGRGRGGRGRGMGRGDGFDSRGKREFDRHSGSDRSGLKHEDKRGGSGSHNWGTVKDELTESPKYIQKQISYNYSDLDQSNVTEETPEGEEHHPVADTENKENEVEEVKEEGPKEMTLDEWKAIQNKDRAKVEFNIRKPNEGADGQWKKGFVLHKSKSEEAHAEDSVMDHHFRKPANDITSQLEINFGDLGRPGRGGRGGRGGCGRGGRPNRGSRTDKSSASAPDVDDPEAFPALA","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":402,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q8NC51","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]

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出荷温度及び保存条件

出荷温度

Dry Ice

短期保存温度

-80°C

長期保存温度

-80°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

False

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

SERBP1 also known as SCR3 is a protein weighing approximately 46 kDa. This protein interacts with specific mRNA sequences acting as a binding protein that influences mRNA stability and modulates the translation process. SERBP1 is widely expressed in various tissues notably in the liver and placenta where it plays a role in cellular activities related to protein synthesis.

Biological function summary

Activities performed by SERBP1 involve regulation of mRNA turnover and translation impacting critical cellular functions. SERBP1 forms part of the ribonucleoprotein complexes which bind to mRNA and stabilize it therefore influencing gene expression. Through these interactions it has a significant impact on the control of translation processes within the cell alongside other regulatory proteins.

Pathways

SERBP1 participates in mRNA surveillance and regulation pathways. This protein interacts with key translation pathways contributing to processes that ensure only properly processed mRNA is translated into proteins. SERBP1's role in these pathways may involve interactions with proteins like eIF4E which also plays a part in translation initiation thereby maintaining cellular homeostasis and efficiency in protein production.

Changes in SERBP1 expression or function can relate to cancer and liver disease. In such conditions aberrant regulation of mRNA stability may occur leading to dysregulated protein synthesis that contributes to pathogenesis. SERBP1 is connected to proteins such as c-Myc in cancer where it may play a role in the overexpression of oncogenes linking these pathway interactions to disease states.

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製品の性状

製品の状態

Liquid

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一般的な情報

機能

Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (PubMed : 36691768). Acts via its association with EEF2/eEF2 factor, sequestering EEF2/eEF2 at the A-site of the ribosome and promoting ribosome stabilization and storage in an inactive state (By similarity). May also play a role in the regulation of mRNA stability : binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay (PubMed : 11001948). Seems to play a role in PML-nuclear bodies formation (PubMed : 28695742).

配列の類似性

Belongs to the SERBP1-HABP4 family.

翻訳後修飾

Phosphorylation by MTOR inhibits SERBP1 and relieves ribosome hibernation.

細胞内局在性

Nucleus

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製品プロトコール

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

See full target information SERBP1

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Abcam product promise

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Recombinant Human SERBP1 protein