AB153408

Recombinant Human Septin 11 protein (GST tag N-Terminus)

Name: Recombinant Human Septin 11 protein (ab153408) | Abcam
Brand: Abcam Limited
SKU: AB153408
Price: 118000 JPY
Availability: InStock

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Recombinant Human Septin 11 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 429 aa range, expressed in Wheat germ, suitable for ELISA, WB.

別名を表示する

SEPT11, SEPTIN11, Septin-11

1 Images

SDS-PAGE - Recombinant Human Septin 11 protein (GST tag N-Terminus) (AB153408)

SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Septin 11 protein (GST tag N-Terminus) (AB153408)

ab153408 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

発現系

Wheat germ

アプリケーション

ELISA, WB

applications

生物活性

アクセッション番号

Q9NVA2

アニマルフリー

キャリアフリー

種

Human

バッファー組成

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

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配列情報

[{"linker":null,"sequence":"MAVAVGRPSNEELRNLSLSGHVGFDSLPDQLVNKSTSQGFCFNILCVGETGIGKSTLMDTLFNTKFESDPATHNEPGVRLKARSYELQESNVRLKLTIVDTVGFGDQINKDDSYKPIVEYIDAQFEAYLQEELKIKRSLFNYHDTRIHACLYFIAPTGHSLKSLDLVTMKKLDSKVNIIPIIAKADTIAKNELHKFKSKIMSELVSNGVQIYQFPTDEETVAEINATMSVHLPFAVVGSTEEVKIGNKMAKARQYPWGVVQVENENHCDFVKLREMLIRVNMEDLREQTHTRHYELYRRCKLEEMGFKDTDPDSKPFSLQETYEAKRNEFLGELQKKEEEMRQMFVMRVKEKEAELKEAEKELHEKFDLLKRTHQEEKKKVEDKKKELEEEVNNFQKKKAAAQLLQSQAQQSGAQQTKKDKDKKNASFT","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":429,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9NVA2","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Proprietary technique

出荷温度

Dry Ice

短期保存温度

-80°C

長期保存温度

-80°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

False

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Septin 11 also known as SEPT11 functions as a GTPase involved in the formation of filamentous structures. This protein has a molecular mass of approximately 49 kDa. It is expressed in a wide range of tissues but most abundantly in the brain. Septin 11 belongs to the septin family which consists of cytoskeletal proteins important for cellular processes like cytokinesis and vesicle trafficking.

Biological function summary

The protein plays a role in cellular structure and integrity forming a complex with other septins to maintain cellular shape and facilitate mitotic processes. Septin 11 participates in organizing the actin cytoskeleton which affects cell division and movement. Its interaction with microtubules also suggests roles in intracellular transport and neural communication.

Pathways

Septin 11 is involved in actin and microtubule dynamics. It interacts with pathways that govern cellular cycle regulation and signal transduction. Related proteins like Septin 2 and Septin 9 play interactive roles in these pathways contributing to the complex orchestration of cellular organization and division. Their coordinated function ensures proper cell cycle progression and developmental processes.

Abnormalities in Septin 11 expression or function link to neurodegenerative diseases and cancer. Dysregulation can contribute to conditions such as Alzheimer's disease potentially through its interactions with tau proteins. Additionally altered Septin 11 expression associates with tumorigenesis as seen in some forms of leukemia where it interacts with proteins like BCR-ABL. Understanding Septin 11’s role in these diseases aids in the development of targeted therapeutic strategies.

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一般的な情報

機能

Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity). During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy.

配列の類似性

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

細胞内局在性

Cytoskeleton

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製品プロトコール

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

See full target information SEPTIN11

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Abcam product promise

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Recombinant Human Septin 11 protein (GST tag N-Terminus)