AB153783

Recombinant Human Semenogelin I protein

Name: Recombinant Human Semenogelin I protein (ab153783) | Abcam
Brand: Abcam Limited
SKU: AB153783
Price: 54000 JPY
Availability: InStock

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Recombinant Human Semenogelin I protein is a Human Fragment protein, in the 24 to 402 aa range, expressed in HEK 293 cells, with >95%, < 0.1 EU/µg endotoxin level, suitable for SDS-PAGE, HPLC.

別名を表示する

SEMG, SEMG1, Semenogelin-1, Cancer/testis antigen 103, Semenogelin I, SGI

Key facts

精製度

>95% SDS-PAGE

ab153783 was determined to be >95% pure by SEC-HPLC and reducing SDS-PAGE.

エンドトキシンレベル

< 0.1 EU/µg

発現系

HEK 293 cells

アプリケーション

HPLC, SDS-PAGE

applications

生物活性

アクセッション番号

P04279

アニマルフリー

キャリアフリー

種

Human

再構成

Reconstitute in PBS

バッファー組成

pH: 4.5 Constituents: 99% Sodium acetate, 0.88% Sodium chloride

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "HPLC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

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配列情報

[{"linker":null,"sequence":"QKGGSKGRLPSEFSQFPHGQKGQHYSGQKGKQQTESKGSFSIQYTYHVDANDHDQSRKSQQYDLNALHKTTKSQRHLGGSQQLLHNKQEGRDHDKSKGHFHRVVIHHKGGKAHRGTQNPSQDQGNSPSGKGISSQYSNTEERLWVHGLSKEQTSVSGAQKGRKQGGSQSSYVLQTEELVANKQQRETKNSHQNKGHYQNVVEVREEHSSKVQTSLCPAHQDKLQHGSKDIFSTQDELLVYNKNQHQTKNLNQDQQHGRKANKISYQSSSTEERRLHYGENGVQKDVSQRSIYSQTEKLVAGKSQIQAPNPKQEPWHGENAKGESGQSTNREQDLLSHEQKGRHQHGSHGGLDIVIIEQEDDSDRHLAQHLNNDQNPLFTVDHHHHHH","proteinLength":"Fragment","predictedMolecularWeight":"43.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":402,"aminoAcidStart":24,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"P04279","tags":[{"tag":"His","terminus":"C-Terminus"}]}]

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出荷温度及び保存条件

製品の状態

Lyophilized

出荷温度

Blue Ice

短期保存温度

-20°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

False

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Semenogelin I sometimes abbreviated as SgI acts mechanically as an important component in the formation of the semen coagulum. This protein has a molecular mass of approximately 52 kDa and is expressed chiefly in the seminal vesicles. After ejaculation Semenogelin I contributes significantly to the formation of a gel-like matrix which plays an important role in the initial viscosity of seminal fluid. Upon the cleavage of Semenogelin I by prostate-specific antigen (PSA) this gel liquefies allowing sperm to achieve motility.

Biological function summary

The primary role of Semenogelin I lies in its involvement in semen coagulation and liquefaction processes. It forms a complex with other seminal plasma proteins to stabilize the gel structure. This structural role ensures that Semenogelin I helps regulate the controlled release and proper function of spermatozoa. Additionally it is implicated in modulating immune system responses against male seminal antigens to prevent adverse reactions in the female reproductive tract.

Pathways

The actions of Semenogelin I integrate it into reproductive and coagulation pathways. In the context of semen coagulation and liquefaction it works closely with PSA which breaks down Semenogelin I and facilitates liquefaction and sperm motility. This process ties Semenogelin I into the prostaglandin signaling pathway which affects reproductive physiology and fertility. Furthermore proteins such as fibronectin and lactoferrin relate to Semenogelin I within these pathways assisting in post-ejaculation changes that enhance sperm function and fertility.

Semenogelin I is linked to fertility issues and prostate cancer. Abnormal levels or altered cleavage patterns can contribute to male infertility potentially through improper semen liquefaction that affects sperm motility. In prostate cancer elevated degradation of Semenogelin I by enzymes like PSA could serve as an indicator of tumor activity and progression. Consequently monitoring Semenogelin I alongside PSA levels can offer insights into both male reproductive health and prostate cancer management.

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一般的な情報

機能

Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA.. Alpha-inhibin-92 and alpha-inhibin-31, derived from the proteolytic degradation of semenogelin, inhibit the secretion of pituitary follicle-stimulating hormone.

配列の類似性

Belongs to the semenogelin family.

翻訳後修飾

Transglutaminase substrate.. Rapidly cleaved after ejaculation by KLK3/PSA, resulting in liquefaction of the semen coagulum and the progressive release of motile spermatozoa.

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製品プロトコール

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

See full target information SEMG1

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Abcam product promise

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Recombinant Human Semenogelin I protein