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AB276428

Recombinant Human SEMA4A protein (His tag)

Recombinant Human SEMA4A protein (His tag)

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Recombinant Human SEMA4A protein (His tag) is a Human Fragment protein, in the 1 to 683 aa range, expressed in HEK 293 cells, with 95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

別名を表示する

SEMAB, SEMB, UNQ783/PRO1317, SEMA4A, Semaphorin-4A, Semaphorin-B, Sema B

1 Images
SDS-PAGE - Recombinant Human SEMA4A protein (His tag) (AB276428)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human SEMA4A protein (His tag) (AB276428)

SDS-PAGE analysis of ab276428

Key facts

精製度

95% HPLC

エンドトキシンレベル

< 1 EU/µg

発現系

HEK 293 cells

タグ

His tag C-Terminus

アプリケーション

SDS-PAGE

applications

生物活性

No

アクセッション番号

Q9H3S1

アニマルフリー

No

キャリアフリー

No

種

Human

バッファー組成

pH: 7.4 Constituents: 95% PBS, 5% Trehalose

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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配列情報

[{"sequence":"MALPALGLDPWSLLGLFLFQLLQLLLPTTTAGGGGQGPMPRVRYYAGDERRALSFFHQKGLQDFDTLLLSGDGNTLYVGAREAILALDIQDPGVPRLKNMIPWPASDRKKSECAFKKKSNETQCFNFIRVLVSYNVTHLYTCGTFAFSPACTFIELQDSYLLPISEDKVMEGKGQSPFDPAHKHTAVLVDGMLYSGTMNNFLGSEPILMRTLGSQPVLKTDNFLRWLHHDASFVAAIPSTQVVYFFFEETASEFDFFERLHTSRVARVCKNDVGGEKLLQKKWTTFLKAQLLCTQPGQLPFNVIRHAVLLPADSPTAPHIYAVFTSQWQVGGTRSSAVCAFSLLDIERVFKGKYKELNKETSRWTTYRGPETNPRPGSCSVGPSSDKALTFMKDHFLMDEQVVGTPLLVKSGVEYTRLAVETAQGLDGHSHLVMYLGTTTGSLHKAVVSGDSSAHLVEEIQLFPDPEPVRNLQLAPTQGAVFVGFSGGVWRVPRANCSVYESCVDCVLARDPHCAWDPESRTCCLLSAPNLNSWKQDMERGNPEWACASGPMSRSLRPQSRPQIIKEVLAVPNSILELPCPHLSALASYYWSHGPAAVPEASSTVYNGSLLLIVQDGVGGLYQCWATENGFSYPVISYWVDSQDQTLALDPELAGIPREHVKVPLTRVSGGAALAAQQSYWPH","proteinLength":"Fragment","predictedMolecularWeight":"73.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":683,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q9H3S1","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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出荷温度及び保存条件

出荷温度
Ambient - Can Ship with Ice
短期保存温度
-20°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
False
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

SEMA4A also known as Semaphorin-4A is a protein that functions as a guidance cue in the immune and nervous systems. It has a molecular mass of approximately 85 kDa. SEMA4A is expressed in various tissues including the retina lung and thymus as well as in several immune cells such as T cells B cells and dendritic cells. This protein plays a significant role in cell signaling affecting cellular processes like axonal guidance and immune responses.
Biological function summary

The interaction of SEMA4A with its receptors such as Plexin B1 and TIM-2 mediates important cellular activities. It is part of the broader semaphorin family which has a role in directing axonal growth during development. This protein contributes to the regulation of immune cell activity including the activation and differentiation of T cells. The presence of SEMA4A influences immune responses highlighting its importance in maintaining immune system balance.

Pathways

SEMA4A engages in the immune system and axon guidance pathways. In the immune system it interacts with proteins like Plexin B1 and CD72 influencing T cell proliferation and function. Through the axon guidance pathway SEMA4A helps direct the growth of nerve fibers impacting neuronal circuit formation. These interactions exemplify SEMA4A's role in linking cell signaling with physiological outcomes.

SEMA4A has connections with retinal degenerative diseases and immune system disorders. Mutations in the SEMA4A gene have been associated with retinitis pigmentosa a retinal disorder leading to vision loss. SEMA4A also plays a role in autoimmune diseases where its interaction with receptors like Plexin B1 affects immune cell function. Understanding the involvement of SEMA4A in these conditions helps in developing potential therapeutic approaches targeting its signaling pathways.
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製品の性状

製品の状態

Lyophilized

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一般的な情報

機能

Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling (By similarity). Regulates glutamatergic and GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner and promotes the development of excitatory synapses in a PLXNB2-dependent manner (By similarity). Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity (By similarity). Promotes phosphorylation of TIMD2 (By similarity). Inhibits angiogenesis (By similarity). Promotes axon growth cone collapse (By similarity). Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (By similarity).

配列の類似性

Belongs to the semaphorin family.

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製品プロトコール

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ターゲットの情報

Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling (By similarity). Regulates glutamatergic and GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner and promotes the development of excitatory synapses in a PLXNB2-dependent manner (By similarity). Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity (By similarity). Promotes phosphorylation of TIMD2 (By similarity). Inhibits angiogenesis (By similarity). Promotes axon growth cone collapse (By similarity). Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (By similarity).
See full target information SEMA4A
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組合せ製品

Primary Antibodies

AB314649

Anti-SEMA4A antibody [EPR27097-20] - BSA and Azide free

RabMAb|Recombinant

Immunoprecipitation - Anti-SEMA4A antibody [EPR27097-20] - BSA and Azide free (AB314649)

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Primary Antibodies

AB75854

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BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UBE2I / UBC9 antibody [EP2938Y] (AB75854)

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SDS-PAGE - Recombinant Human HPD protein (AB99868)

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