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AB135221

Recombinant ヒト SCYL1 protein (GST tag N-Terminus)

Recombinant Human SCYL1 protein (GST tag N-Terminus)

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Recombinant Human SCYL1 protein (GST tag N-Terminus) is a Human Fragment protein, in the 1 to 556 aa range, expressed in Baculovirus infected Sf9 cells, with >95%, suitable for SDS-PAGE, WB.

別名を表示する

CVAK90, GKLP, NTKL, TAPK, TEIF, TRAP, HT019, SCYL1, N-terminal kinase-like protein, Coated vesicle-associated kinase of 90 kDa, SCY1-like protein 1, Telomerase regulation-associated protein, Telomerase transcriptional element-interacting factor, Teratoma-associated tyrosine kinase

1 Images
SDS-PAGE - Recombinant Human SCYL1 protein (GST tag N-Terminus) (AB135221)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human SCYL1 protein (GST tag N-Terminus) (AB135221)

SDS-PAGE analysis of ab135221.

Key facts

精製度

>95% SDS-PAGE

発現系

Baculovirus infected Sf9 cells

タグ

GST tag N-Terminus

アプリケーション

SDS-PAGE, WB

applications

生物活性

No

アクセッション番号

Q96KG9

アニマルフリー

No

キャリアフリー

No

種

Human

バッファー組成

pH: 7.5 Constituents: 25% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.79% Tris HCl, 0.31% Glutathione, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF

storage-buffer

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組合せ製品

Primary Antibodies

AB95074

Anti-SCYL1 antibody

Immunoprecipitation - Anti-SCYL1 antibody (AB95074)

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Proteins & Peptides

AB165536

Recombinant Human TMED6 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human TMED6 protein (GST tag N-Terminus) (AB165536)

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  • 0
Proteins & Peptides

AB114304

Recombinant Human Nav1.7 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human Nav1.7 protein (GST tag N-Terminus) (AB114304)

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  • 0
Proteins & Peptides

AB268701

Recombinant Mouse KDM4B / JMJD2B protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Mouse KDM4B / JMJD2B protein (Tagged) (AB268701)

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  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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配列情報

[{"linker":null,"sequence":"MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLHVVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPELEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSNRFVETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKVLPQLLTAFEFGNAGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSSTDRAMRIRLLQQMEQFIQYLDEPTVNTQIFPHVVHGFLDTNPAIREQTVKSMLLLAPKLNEANLNVELMKHFARLQAKDEQGPIRCNTTVCLGKIGSYLSASTRHRVLTSAFSRATRDPFAPSRVAGVLGFAATHNLYSMNDCAQKILPVLCGLTVDPEKSVRDQAFKAIRSFLSKLESVSEDPTQLEEVEKDVHA","proteinLength":"Fragment","predictedMolecularWeight":"85 kDa","actualMolecularWeight":null,"aminoAcidEnd":556,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Baculovirus infected Sf9 cells","accessionNumber":"Q96KG9","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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出荷温度及び保存条件

製品の状態
Liquid
出荷温度
Dry Ice
短期保存温度
-80°C
長期保存温度
-80°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
False
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

SCYL1 also known as Scy1 Like Pseudokinase 1 is a pseudokinase with a molecular mass of approximately 95 kDa. It localizes primarily to the cytoplasm and is strongly expressed in the central nervous system liver and kidney. The protein possesses several phosphorylation sites and a characteristic N-terminal kinase-like domain although it lacks the typical catalytic activity of kinases. SCYL1 appears to be involved in cellular processes related to protein trafficking and stability.
Biological function summary

SCYL1 contributes to the sorting and transport of proteins between the Golgi apparatus and the endoplasmic reticulum. It interacts with coatomer complexes to facilitate vesicular trafficking ensuring proper cellular function and protein homeostasis. As part of the cellular transport machinery SCYL1 helps maintain the structural integrity of the Golgi complex and likely plays role in neurodevelopment due to its expression patterns and involvement in protein handling.

Pathways

SCYL1 influences the Golgi-to-ER transport pathways and is involved in vesicle formation and movement. It works alongside proteins like coatomer protein complex subunits to maintain efficient vesicular transport within the cell. Through these pathways SCYL1 connects to broader cellular functions like protein sorting and endosome-to-Golgi retrieval contributing to the systematic recycling and allocation of proteins across the cellular framework.

SCYL1 mutations link the protein to spinocerebellar ataxia type 21 and the hepatic disorder 3C syndrome. These conditions highlight the protein's connections to neurological and liver functions reflecting its significant role in these organs. Additionally interactions with proteins like TDP-43 suggest potential contributions to neurodegenerative processes when misregulated. Understanding SCYL1's role in these diseases provides insight into its importance for normal cellular functioning and the consequences of its dysfunction.
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一般的な情報

機能

Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum (PubMed : 18556652). Involved in the maintenance of the Golgi apparatus morphology (PubMed : 26581903).. Isoform 6. Acts as a transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region.

配列の類似性

Belongs to the protein kinase superfamily.

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製品プロトコール

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ターゲットの情報

Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum (PubMed : 18556652). Involved in the maintenance of the Golgi apparatus morphology (PubMed : 26581903).. Isoform 6. Acts as a transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region.
See full target information SCYL1
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