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Recombinant Human RHEB protein (ab78768)

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SDS-PAGE - Recombinant Human RHEB protein (ab78768)

    Key features and details

    • Expression system: Escherichia coli
    • Purity: > 95% SDS-PAGE
    • Tags: T7 tag N-Terminus
    • Suitable for: SDS-PAGE

    製品の詳細

    • 製品名

      Recombinant Human RHEB protein
      RHEB タンパク質・ペプチド 製品一覧

    • 精製度

      > 95 % SDS-PAGE.
      ab78768 is purified using conventional chromatography techniques.

    • 発現系

      Escherichia coli

    • タンパク質長

      Full length protein

    • Animal free

      No

    • 由来

      Recombinant

      • 生物種

        Human

      • 配列

        MASMTGGQQM GRGSASMPQS KSRKIAILGY RSVGKSSLTI QFVEGQFVDS YDPTIENTFT KLITVNGQEY HLQLVDTAGQ DEYSIFPQTY SIDINGYILV YSVTSIKSFE VIKVIHGKLL DMVGKVQIPI MLVGNKKDLH MERVISYEEG KALAESWNAA FLESSAKENQ TAVDVFRRII LEAEKMDGAA SQGKSSC

      • タグ

        T7 tag N-Terminus

    特性

    Our Abpromise guarantee covers the use of ab78768 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • アプリケーション

      SDS-PAGE

    • 製品の状態

      Liquid
    • Concentration information loading...

    前処理および保存

    • 保存方法および安定性

      Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

      pH: 8.00
      Constituents: 0.0154% DTT, 0.242% Tris, 10% Glycerol (glycerin, glycerine)

    関連情報

    • 別名

      • Ras homolog enriched in brain 2, formerly
      • GTP binding protein Rheb
      • GTP-binding protein Rheb
      • MGC111559
      • Ras homolog enriched in brain
      • Ras homolog enriched in brain 2
      • Rheb
      • RHEB 2
      • RHEB_HUMAN
      • RHEB2
      • RHEB2, formerly
      see all

    • 機能

      Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Activates the protein kinase activity of mTORC1. Has low intrinsic GTPase activity.

    • 組織特異性

      Ubiquitous. Highest levels observed in skeletal and cardiac muscle.

    • 配列類似性

      Belongs to the small GTPase superfamily. Rheb family.

    • 翻訳後修飾

      Farnesylation is important for efficiently activating mTORC1-mediated signaling.

    • 細胞内局在

      Cell membrane.
    • Information by UniProt

    画像

    • SDS-PAGE - Recombinant Human RHEB protein (ab78768)
      SDS-PAGE - Recombinant Human RHEB protein (ab78768)
      15% SDS-PAGE showing ab76768 at approximately 22kDa (3µg).

    プロトコール

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    参考文献 (1)

    ab78768 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab78768 は 1 報の論文で使用されています。

    • Chalkiadaki K  et al. Mnk1/2 kinases regulate memory and autism-related behaviours via Syngap1. Brain N/A:N/A (2022). PubMed: 36315645

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