JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB159342

Recombinant Human RGS7 protein (GST tag N-Terminus)

Recombinant Human RGS7 protein (GST tag N-Terminus)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human RGS7 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 487 aa range, expressed in Wheat germ, suitable for ELISA, WB.

別名を表示する

Regulator of G-protein signaling 7, RGS7

1 Images
SDS-PAGE - Recombinant Human RGS7 protein (GST tag N-Terminus) (AB159342)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human RGS7 protein (GST tag N-Terminus) (AB159342)

ab159342 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

発現系

Wheat germ

タグ

GST tag N-Terminus

アプリケーション

ELISA, WB

applications

生物活性

No

アクセッション番号

P49802

アニマルフリー

No

キャリアフリー

No

種

Human

バッファー組成

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

配列情報

[{"sequence":"MAQGNNYGQTSNGVADESPNMLVYRKMEDVIARMQDEKNGIPIRTVKSFLSKIPSVFSGSDIVQWLIKNLTIEDPVEALHLGTLMAAHGYFFPISDHVLTLKDDGTFYRFQTPYFWPSNCWEPENTDYAVYLCKRTMQNKARLELADYEAESLARLQRAFARKWEFIFMQAEAQAKVDKKRDKIERKILDSQERAFWDVHRPVPGCVNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTTHNVKEPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQAKKKSGNSMDRRTSFEKFAQNVGKSLTSKRLTSLAQSY","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":487,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P49802","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
style
left-column

出荷温度及び保存条件

出荷温度
Dry Ice
短期保存温度
-80°C
長期保存温度
-80°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
False
style
left-column

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Regulator of G protein signaling 7 (RGS7) also known as RGP7 is a member of the R7 family of RGS proteins with a molecular weight of approximately 85 kDa. RGS7 regulates G protein signaling by accelerating the deactivation of Gα subunits through its GTPase-activating protein activity. It is widely expressed in the central nervous system especially in the brain regions like the hippocampus and basal ganglia.
Biological function summary

G protein-coupled receptor (GPCR) signaling modulation is an important role of RGS7. It forms a complex with the Gβ5 subunit and other anchoring proteins to regulate synaptic transmission and neuronal excitability. This complex localizes to synaptic sites and modifies neurotransmitter release which can influence cognitive functions and behaviors. RGS7 helps in maintaining signal fidelity within neural circuits.

Pathways

G protein-coupled receptor signaling and neurotransmitter release are two important biological pathways involving RGS7. In the GPCR signaling pathway RGS7 modulates GPCR response by interacting with Gα subunits to accelerate their inactivation. Interaction with neurotransmitter release pathways occurs as RGS7 controls calcium influx and synaptic vesicle fusion. It relates to proteins such as Gβ5 and other G protein subunits playing key roles in these pathways.

Research indicates that RGS7 is connected to certain neurological conditions such as addiction and depression. Dysregulation of RGS7 may alter neurotransmitter systems influencing susceptibility to addictive substances and mood disorders. RGS7 interacts with proteins such as Gβ5 which are also involved in the dysregulation seen in these conditions. Understanding the functions of RGS7 can inform therapeutic strategies for these diseases.
style
left-column

製品の性状

製品の状態

Liquid

style
left-column

一般的な情報

機能

GTPase activator component of the RGS7-GNB5 complex that regulates G protein-coupled receptor signaling cascades (PubMed : 10521509, PubMed : 10862767, PubMed : 31189666). The RGS7-GNB5 complex acts as an inhibitor signal transduction by promoting the GTPase activity of G protein alpha subunits, such as GNAO1, thereby driving them into their inactive GDP-bound form (PubMed : 10521509, PubMed : 10862767). May play a role in synaptic vesicle exocytosis (Probable) (PubMed : 12659861). Glycine-dependent regulation of the RGS7-GNB5 complex by GPR158 affects mood and cognition via its ability to regulate neuronal excitability in L2/L3 pyramidal neurons of the prefrontal cortex (By similarity). Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling (PubMed : 15897264).

翻訳後修飾

Palmitoylated.. Ubiquitinated, leading to rapid proteasomal degradation.. Phosphorylation and subsequent interaction with 14-3-3 proteins inhibits GAP activity.

style
left-column

製品プロトコール

style
left-column

ターゲットの情報

GTPase activator component of the RGS7-GNB5 complex that regulates G protein-coupled receptor signaling cascades (PubMed : 10521509, PubMed : 10862767, PubMed : 31189666). The RGS7-GNB5 complex acts as an inhibitor signal transduction by promoting the GTPase activity of G protein alpha subunits, such as GNAO1, thereby driving them into their inactive GDP-bound form (PubMed : 10521509, PubMed : 10862767). May play a role in synaptic vesicle exocytosis (Probable) (PubMed : 12659861). Glycine-dependent regulation of the RGS7-GNB5 complex by GPR158 affects mood and cognition via its ability to regulate neuronal excitability in L2/L3 pyramidal neurons of the prefrontal cortex (By similarity). Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling (PubMed : 15897264).
See full target information Regulator of G-protein signaling 7
style
left-column
style
left-column
style
right-column

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com