Recombinant Human RGS10 protein (His tag N-Terminus)
Recombinant Human RGS10 protein (His tag N-Terminus)
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Recombinant Human RGS10 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 181 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
別名を表示する
Regulator of G-protein signaling 10, RGS10
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human RGS10 protein (His tag N-Terminus) (AB109947)
ab109947 at 3 ug on an SDS-PAGE gel (15%)
Reactivity data
配列情報
出荷温度及び保存条件
出荷温度
短期保存温度
長期保存温度
分注に関する情報
保管に関する情報
補足情報
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
RGS10 plays a role in immune responses and neural function. It is not typically part of larger protein complexes but it interacts independently with other proteins in cellular signaling pathways. In the immune system RGS10 influences various processes such as cytokine production and leukocyte function. In neurons RGS10 contributes to maintaining neural signaling by regulating neurotransmitter-related G-protein coupled receptor pathways.
Pathways
G-protein signaling pathways and the MAPK signaling pathway include RGS10 as an important regulatory protein. It modulates the G-protein coupled receptor signaling pathway an important aspect of cellular response to external stimuli. RGS10 also influences the PI3K-Akt signaling pathway by regulating upstream signaling events. These pathways involve proteins such as G alpha subunits and PI3 kinase which interact with RGS10 to control diverse physiological processes.
製品の性状
製品の状態
Liquid
補足情報
ab109947 was purified by using anion-exchange chromatography (DEAE sepharose resin) and gel-filtration chromatography (Sephacryl S-200) with 20mM Tris pH 7.5, 2mM EDTA.
一般的な情報
機能
Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed : 10608901, PubMed : 11443111, PubMed : 18434541, PubMed : 8774883, PubMed : 9353196). Modulates the activity of potassium channels that are activated in response to CHRM2 signaling (PubMed : 11443111). Activity on GNAZ is inhibited by palmitoylation of the G-protein (PubMed : 9353196).
細胞内局在性
Nucleus
ターゲットの情報
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