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Recombinant Human Renin Receptor protein (ab153053)

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SDS-PAGE - Recombinant Human Renin Receptor protein (ab153053)

    Key features and details

    • Expression system: Wheat germ
    • Tags: GST tag N-Terminus
    • Suitable for: ELISA, WB

    製品の詳細

    • 製品名

      Recombinant Human Renin Receptor protein
      Renin Receptor タンパク質・ペプチド 製品一覧

    • 発現系

      Wheat germ

    • タンパク質長

      Full length protein

    • Animal free

      No

    • 由来

      Recombinant

      • 生物種

        Human

      • 配列

        MAVFVVLLALVAGVLGNEFSILKSPGSVVFRNGNWPIPGERIPDVAALSM GFSVKEDLSWPGLAVGNLFHRPRATVMVMVKGVNKLALPPGSVISYPLEN AVPFSLDSVANSIHSLFSEETPVVLQLAPSEERVYMVGKANSVFEDLSVT LRQLRNRLFQENSVLSSLPLNSLSRNNEVDLLFLSELQVLHDISSLLSRH KHLAKDHSPDLYSLELAGLDEIGKRYGEDSEQFRDASKILVDALQKFADD MYSLYGGNAVVELVTVKSFDTSLIRKTRTILEAKQAKNPASPYNLAYKYN FEYSVVFNMVLWIMIALALAVIITSYNIWNMDPGYDSIIYRMTNQKIRMD

      • 領域

        1 to 350

      • タグ

        GST tag N-Terminus

    特性

    Our Abpromise guarantee covers the use of ab153053 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • アプリケーション

      ELISA

      Western blot

    • 製品の状態

      Liquid

    • 備考

      This product was previously labelled as POU3F2.

       

    • Concentration information loading...

    前処理および保存

    • 保存方法および安定性

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      pH: 8.00
      Constituents: 0.31% Glutathione, 0.79% Tris HCl

    関連情報

    • 別名

      • APT6M8 9
      • APT6M8-9
      • ATP6AP2
      • ATP6IP2
      • ATP6M8-9
      • ATPase H(+)-transporting lysosomal accessory protein 2
      • ATPase H(+)-transporting lysosomal-interacting protein 2
      • ATPase H+ transporting lysosomal accessory protein 2
      • ATPase H+ transporting lysosomal interacting protein 2
      • ATPase H+ transporting lysosomal vacuolar proton pump membrane sector associated protein M8 9
      • ATPase membrane sector associated protein M8 9
      • ATPase, H+ transporting, lysosomal (vacuolar proton pump) membrane sector associated protein M8 9
      • CAPER
      • ELDF10
      • Embryonic liver differentiation factor 10
      • ER localized type I transmembrane adaptor
      • ER-localized type I transmembrane adaptor
      • HT028
      • M8 9
      • M8-9
      • MGC99577
      • MRXE
      • MSTP009
      • N14F
      • Renin receptor
      • Renin/prorenin receptor
      • RENR_HUMAN
      • V ATPase M8 9 subunit
      • V ATPase M8.9 subunit
      • V-ATPase M8.9 subunit
      • Vacuolar ATP synthase membrane sector associated protein M8 9
      • Vacuolar ATP synthase membrane sector-associated protein M8-9
      • vacuolar proton ATP synthase membrane sector associated protein M8 9
      • XMRE
      see all

    • 機能

      Functions as a renin and prorenin cellular receptor. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS).

    • 組織特異性

      Expressed in brain, heart, placenta, liver, kidney and pancreas. Barely detectable in lung and skeletal muscles. In the kidney cortex it is restricted to the mesangium of glomeruli. In the coronary and kidney artery it is expressed in the subendothelium, associated to smooth muscles where it colocalizes with REN. Expressed in vascular structures and by syncytiotrophoblast cells in the mature fetal placenta.

    • 関連疾患

      Defects in ATP6AP2 are a cause of mental retardation X-linked with epilepsy (MRXE) [MIM:300423]. MRXE is a syndromic mental retardation. Patients manifest mild to moderate mental retardation associated with epilepsy, delays in motor milestones and speech acquisition in infancy.

    • 翻訳後修飾

      Phosphorylated.

    • 細胞内局在

      Membrane.
    • Information by UniProt

    画像

    • SDS-PAGE - Recombinant Human Renin Receptor protein (ab153053)
      SDS-PAGE - Recombinant Human Renin Receptor protein (ab153053)
      ab153053 on a 12.5% SDS-PAGE stained with Coomassie Blue.

    プロトコール

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    参考文献 (0)

    ab153053 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab153053 は論文での使用が確認できていません。

    レビューと Q&A

    Show All レビュー Q&A
    レビューを送る 質問を送る

    Evaluation of recombinant ATP6IP2 effect on CHO-M2 cell line viability

     Excellent
    Abreviews
    abreview image
    Application
    Other - Do not use
    The effect of recombinant protein on cell viability is assessed using MTS viability determination method on cultured CHO-M2 cells, incubated 42h in presence of different concentrations (45.5 – 22.7 – 11.4 – 5.7 – 2.8 – 1.4 nM) of rATP6IP2.

    CONCLUSION
    The viability is similar for the different concentration of rATP6IP2. It doesn’t affect cell viability.
    The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.

    Abcam user community

    Verified customer

    投稿 Aug 26 2016

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