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AB181938

Recombinant Human RanBP3 protein (His tag N-Terminus)

Recombinant Human RanBP3 protein (His tag N-Terminus)

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Recombinant Human RanBP3 protein (His tag N-Terminus) is a Human Fragment protein, in the 235 to 445 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

別名を表示する

Ran-binding protein 3, RanBP3, RANBP3

1 Images
SDS-PAGE - Recombinant Human RanBP3 protein (His tag N-Terminus) (AB181938)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human RanBP3 protein (His tag N-Terminus) (AB181938)

15% SDS-PAGE analysis of 3 μg ab181938 .

Key facts

精製度

>95% SDS-PAGE

ab181938 was purified using conventional chromatography techniques.

発現系

Escherichia coli

タグ

His tag N-Terminus

アプリケーション

SDS-PAGE, Mass Spec

applications

生物活性

No

アクセッション番号

Q9H6Z4

アニマルフリー

No

キャリアフリー

No

種

Human

バッファー組成

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl

storage-buffer

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組合せ製品

Primary Antibodies

AB134052

Anti-RanBP3 antibody [EPR5088(2)]

RabMAb|Recombinant|Trial Size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RanBP3 antibody [EPR5088(2)] (AB134052)

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Proteins & Peptides

AB185825

Recombinant Human NEDD8 protein

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Proteins & Peptides

AB101206

Recombinant Human SRP14 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human SRP14 protein (His tag N-Terminus) (AB101206)

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Proteins & Peptides

AB152829

Recombinant Human BAT3/BAG-6 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human BAT3/BAG-6 protein (GST tag N-Terminus) (AB152829)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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配列情報

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMGSISSSLENSTNSADASSNKFVFGQNMSERVLSPPKLNEVSSDANRENAAAESGSESSSQEATPEKESLAESAAAYTKATARKCLLEKVEVITGEEAESNVLQMQCKLFVFDKTSQSWVERGRGLLRLNDMASTDDGTLQSRLVMRTQGSLRLILNTKLWAQMQIDKASEKSIRITAMDTEDQGVKVFLISASSKDTGQLYAALHHRILALRS","proteinLength":"Fragment","predictedMolecularWeight":"25.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":445,"aminoAcidStart":235,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9H6Z4","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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出荷温度及び保存条件

製品の状態
Liquid
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
False
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

RanBP3 also known as Ran-binding protein 3 functions as a Ran-dependent nuclear export factor. It has a molecular weight of around 58 kDa. It specifically facilitates the export of proteins and RNAs from the nucleus to the cytoplasm interacting directly with the Ran GTPase. RanBP3 is ubiquitously expressed in many tissue types indicating its significant role across various cellular processes. It serves as an adapter in the formation of export complexes binding to export receptors and the cargo.
Biological function summary

RanBP3 modulates cargo recognition and assembly of export complexes. It plays a role in the nuclear transport of proteins impacting gene regulation and cell cycle progression. As part of a larger export complex RanBP3 works together with exportin-1 and the GTP-bound form of Ran to mediate the nuclear export process efficiently. This targeted export contributes to maintaining cellular homeostasis and influences cellular responses to environmental changes.

Pathways

RanBP3 importantly participates in the nucleocytoplasmic transport pathway. This pathway is important for the regulation of gene expression and signal transduction. RanBP3 interacts with proteins such as exportin-1 (CRM1) and CAS which coordinate the nuclear export of various proteins and RNAs. The pathway ensures the proper distribution of cellular components which is essential for cell function and survival.

RanBP3 associates with conditions like cancer and viral infections. Alterations in RanBP3 expression or function can lead to dysregulation of nuclear export impacting cell proliferation and apoptosis as observed in cancer. RanBP3's interaction with importin-beta and exportin-1 can influence the cellular response to viral infections as viruses often exploit nuclear export pathways for replication. Understanding these associations could lead to potential therapeutic interventions targeting RanBP3 activities.
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一般的な情報

機能

Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export.

翻訳後修飾

Phosphorylation at Ser-126 promotes its import into the nucleus.

細胞内局在性

Nucleus

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製品プロトコール

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ターゲットの情報

Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export.
See full target information RANBP3
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Abcam product promise

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