AB227416

Recombinant Human RAET1E protein (Fc Chimera His Tag)

Name: Recombinant Human RAET1E protein (Fc Chimera His Tag) (ab227416) | Abcam
Brand: Abcam Limited
SKU: AB227416
Price: 92000 JPY
Availability: InStock

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(0 Publication)

Recombinant Human RAET1E protein (Fc Chimera His Tag) is a Human Fragment protein, in the 31 to 225 aa range, expressed in Baculovirus infected insect cells, with >85%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

別名を表示する

LETAL, N2DL4, ULBP4, UNQ1867/PRO4303, RAET1E, Retinoic acid early transcript 1E, Lymphocyte effector toxicity activation ligand, NKG2D ligand 4, RAE-1-like transcript 4, UL16-binding protein 4, N2DL-4, NKG2DL4

1 Images

SDS-PAGE - Recombinant Human RAET1E protein (Fc Chimera His Tag) (AB227416)

SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human RAET1E protein (Fc Chimera His Tag) (AB227416)

15% SDS-PAGE analysis of 3 μg ab227416.

MW 57-70 kDa (SDS-PAGE under reducing conditions).

Key facts

精製度

>85% SDS-PAGE

エンドトキシンレベル

< 1 EU/µg

発現系

Baculovirus infected insect cells

アプリケーション

SDS-PAGE

applications

生物活性

アクセッション番号

Q8TD07

アニマルフリー

キャリアフリー

種

Human

バッファー組成

pH: 7.4 Constituents: PBS, 10% Glycerol (glycerin, glycerine)

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

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製品の詳細

This product was previously labelled as ULBP4

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配列情報

[{"sequence":"ADPHSLCFNFTIKSLSRPGQPWCEAQVFLNKNLFLQYNSDNNMVKPLGLLGKKVYATSTWGELTQTLGEVGRDLRMLLCDIKPQIKTSDPSTLQVEMFCQREAERCTGASWQFATNGEKSLLFDAMNMTWTVINHEASKIKETWKKDRGLEKYFRKLSKGDCDHWLREFLGHWEAMPEPTVSPVNASDIHWSSSSLPDVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKHHHHHH","proteinLength":"Fragment","predictedMolecularWeight":"49.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":225,"aminoAcidStart":31,"nature":"Recombinant","expressionSystem":"Baculovirus infected insect cells","accessionNumber":"Q8TD07","tags":[{"tag":"Fc","terminus":"C-Terminus"},{"tag":"His","terminus":"C-Terminus"}]}]

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出荷温度及び保存条件

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

False

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

RAET1E also known as UL16-binding protein 4 (ULBP4) is a member of the MHC class I-related molecules. It has a molecular mass of approximately 31 kDa. RAET1E is part of the family of proteins that acts as a ligand for the NKG2D receptor found on the surface of natural killer (NK) cells. In terms of expression RAET1E is present on the surface of various cell types especially in stressed transformed or virus-infected cells where it signals cellular distress to immune cells.

Biological function summary

RAET1E plays a role in immune surveillance. It is involved in the activation of NK cells when it binds to the NKG2D receptor. This interaction is part of the body's defense mechanism against transformed or infected cells. RAET1E operates in isolation rather than as part of a larger protein complex which allows it to independently initiate the immune response when detecting harmful cells.

Pathways

RAET1E functions within the innate immune response pathway. It works closely with the NKG2D signaling pathway which is important for the activation of cytotoxic activities in immune cells. RAET1E through its binding to NKG2D facilitates the destruction of malignant cells. This connection places RAET1E alongside other similar NKG2D ligands such as MIC and other ULBP family proteins which contribute to the activation of NK and T cells.

RAET1E is linked to various cancer types and infectious diseases. Its expression on the surface of tumor cells can signal NK cells to target and destroy these potentially harmful cells. In certain cancers the loss or reduction of RAET1E expression may allow tumor cells to escape immune detection. In viral infections the upregulation of RAET1E on infected cells assists in the clearance of viruses by NK cells. Both in cancer and viral infections proteins like RAET1E and NKG2D play an important part in the immune system's defensive strategies.

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製品の性状

製品の状態

Liquid

補足情報

Affinity purified

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一般的な情報

機能

Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.

配列の類似性

Belongs to the MHC class I family.

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製品プロトコール

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.

See full target information RAET1E

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Abcam product promise

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Recombinant Human RAET1E protein (Fc Chimera His Tag)