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AB177671

Recombinant Human Procathepsin W protein (denatured) (His tag N-Terminus)

Recombinant Human Procathepsin W protein (denatured) (His tag N-Terminus)

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Recombinant Human Procathepsin W protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 22 to 376 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

別名を表示する

Cathepsin W, Lymphopain, CTSW

1 Images
SDS-PAGE - Recombinant Human Procathepsin W protein (denatured) (His tag N-Terminus) (AB177671)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human Procathepsin W protein (denatured) (His tag N-Terminus) (AB177671)

15% SDS-PAGE analysis of ab177671 (3μg).

Key facts

精製度

>85% SDS-PAGE

発現系

Escherichia coli

タグ

His tag N-Terminus

アプリケーション

SDS-PAGE

applications

生物活性

No

アクセッション番号

P56202

アニマルフリー

No

キャリアフリー

No

Human

バッファー組成

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

配列情報

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSIRGPLRAQDLGPQPLELKEAFKLFQIQFNRSYLSPEEHAHRLDIFAHNLAQAQRLQEEDLGTAEFGVTPFSDLTEEEFGQLYGYRRAAGGVPSMGREIRSEEPEESVPFSCDWRKVAGAISPIKDQKNCNCCWAMAAAGNIETLWRISFWDFVDVSVQELLDCGRCGDGCHGGFVWDAFITVLNNSGLASEKDYPFQGKVRAHRCHPKKYQKVAWIQDFIMLQNNEHRIAQYLATYGPITVTINMKPLQLYRKGVIKATPTTCDPQLVDHSVLLVGFGSVKSEEGIWAETVSSQSQPQPPHPTPYWILKNSWGAQWGEKGYFRLHRGSNTCGITKFPLTARVQKPDMKPRVSCPP","proteinLength":"Full Length","predictedMolecularWeight":"42 kDa","actualMolecularWeight":null,"aminoAcidEnd":376,"aminoAcidStart":22,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P56202","tags":[{"tag":"His","terminus":"N-Terminus"}]}]

出荷温度及び保存条件

出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
False

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Procathepsin W also known as Cathepsin W is a lysosomal cysteine protease with a molecular mass of approximately 35 kDa. This enzyme is mainly expressed in cells of the immune system specifically in cytotoxic T lymphocytes and natural killer cells. The expression of Procathepsin W in these cells suggests a role in cytolytic activity. The gene encoding this protease is located on chromosome 11 and shares homology with other members of the cathepsin family.
Biological function summary

Procathepsin W acts as part of the immune system's machinery for degrading proteins. Although it is not directly involved in any known complexes it functions within the acidic environment of lysosomes. As a protease Procathepsin W helps break down proteins into smaller peptides or amino acids enabling the immune system to process antigens or eliminate damaged proteins. Its activity in immune cells indicates its relevance to immune responses aiding in cell killing processes.

Pathways

Procathepsin W plays a role in the antigen processing and presentation pathway which is important for immune surveillance. It interacts with other proteins such as major histocompatibility complex (MHC) molecules to present peptides to T cells contributing to the adaptive immune response. The enzyme is also indirectly linked to apoptosis through its participation in protein degradation sharing this pathway with other proteases like caspases that facilitate programmed cell death.

Procathepsin W shows relevance in conditions involving the immune system. Alterations in its expression or function may contribute to immune-related disorders such as autoimmune diseases or certain types of cancer. Connections between Procathepsin W and proteins like granzyme B highlight its potential involvement in tumor surveillance and elimination by the immune system. Understanding these interactions can provide insight into therapeutic targets for modulating immune functions in related diseases.

製品の性状

製品の状態

Liquid

一般的な情報

機能

May have a specific function in the mechanism or regulation of T-cell cytolytic activity.. (Microbial infection) Plays a role during influenza virus infection in lungs cells ex vivo. Acts at the level of virus entering host cytoplasm from late endosome.

配列の類似性

Belongs to the peptidase C1 family.

製品プロトコール

ターゲットの情報

May have a specific function in the mechanism or regulation of T-cell cytolytic activity.. (Microbial infection) Plays a role during influenza virus infection in lungs cells ex vivo. Acts at the level of virus entering host cytoplasm from late endosome.
See full target information CTSW

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