AB196412

Recombinant Human PRDM12 protein (GST tag N-Terminus)

Name: Recombinant Human PRDM12 protein (ab196412) | Abcam
Brand: Abcam Limited
SKU: AB196412
Price: 246000 JPY
Availability: InStock

Be the first to review this product! Submit a review

(0 Publication)

Recombinant Human PRDM12 protein (GST tag N-Terminus) is a Human Fragment protein, in the 2 to 243 aa range, expressed in Escherichia coli, with >50%, suitable for SDS-PAGE.

別名を表示する

PFM9, PRDM12, PR domain zinc finger protein 12, PR domain-containing protein 12

1 Images

SDS-PAGE - Recombinant Human PRDM12 protein (GST tag N-Terminus) (AB196412)

SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human PRDM12 protein (GST tag N-Terminus) (AB196412)

4-20% SDS-PAGE analysis of 2 μg ab196412 with Coomassie staining.

Key facts

精製度

>50% SDS-PAGE

発現系

Escherichia coli

アプリケーション

SDS-PAGE

applications

生物活性

アクセッション番号

Q9H4Q4

アニマルフリー

キャリアフリー

種

Human

バッファー組成

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.64% Sodium chloride, 0.63% Tris HCl, 0.04% Sorbitan monolaurate, ethoxylated, 0.02% Potassium chloride

storage-buffer

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

style

left-column

style

left-column

配列情報

[{"sequence":"MSPILGYWKIKGLVQPTRLLLEYLEEKYEEHLYERDEGDKWRNKKFELGLEFPNLPYYIDGDVKLTQSMAIIRYIADKHNMLGGCPKERAEISMLEGAVLDIRYGVSRIAYSKDFETLKVDFLSKLPEMLKMFEDRLCHKTYLNGDHVTHPDFMLYDALDVVLYMDPMCLDAFPKLVCFKKRIEAIPQIDKYLKSSKYIAWPLQGWQATFGGGDHPPKSDLEVLFQ^GPLGSMGSVLPAEALVLKTGLKAPGLALAEVITSDILHSFLYGRWRNVLGEQLFEDKSHHASPKTAFTAEVLAQSFSGEVQKLSSLVLPAEVIIAQSSIPGEGLGIFSKTWIKAGTEMGPFTGRVIAPEHVDICKNNNLMWEVFNEDGTVRYFIDASQEDHRSWMTYIKCARNEQEQNLEVVQIGTSIFYKAIEMIPPDQELLVWYGNSHNTFLGIPGVPGLEEDQKKNKHEDFHPADSAAGPAGRM","proteinLength":"Fragment","predictedMolecularWeight":"54 kDa","actualMolecularWeight":null,"aminoAcidEnd":243,"aminoAcidStart":2,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9H4Q4","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]

style

left-column

出荷温度及び保存条件

出荷温度

Dry Ice

短期保存温度

-80°C

長期保存温度

-80°C

保管に関する情報

Avoid freeze / thaw cycle

False

style

left-column

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

PRDM12 also known as PR domain containing 12 is a transcriptional regulator believed to have a mass of approximately 88 kDa. It functions mechanically by modulating gene expression through histone methylation. PRDM12 localizes in the nucleus and is primarily expressed in the nervous system notably in sensory neurons. It acts by interacting with other factors to influence the chromatin structure thereby modifying how genes get transcribed.

Biological function summary

PRDM12 plays a significant role in neural development and differentiation. It is a part of the PRDM family which is involved in various cellular processes through its interaction with cofactors. PRDM12 interacts to modulate neural gene expression contributing to the formation and maintenance of neural tissues. It does not function alone and requires protein partners forming complexes to execute its regulating tasks effectively within the cell.

Pathways

The activity of PRDM12 integrates into developmental signaling networks including the Notch and Wnt pathways. These pathways are critical for neural differentiation and cellular fate decision indicating PRDM12's involvement in neurogenesis. It interacts with proteins like Notch1 and β-catenin—key components in these pathways—to regulate downstream effects related to nerve cell specification and growth.

Mutations or dysregulation of PRDM12 have connections to congenital insensitivity to pain where patients cannot feel physical pain. This condition highlights PRDM12's importance in sensory neuron function. Another condition associated is peripheral neuropathy where the integrity of peripheral nerves is compromised. Here interactions with the TrkA protein which influences nerve growth factor receptor binding showcase PRDM12's role in disease contexts related to nerve health and functionality.

style

left-column

製品の性状

製品の状態

Liquid

style

left-column

一般的な情報

機能

Transcriptional regulator necessary for the development of nociceptive neurons, playing a key role in determining the nociceptive lineage from neural crest cell progenitors. Initiates neurogenesis and activates downstream pro-neuronal transcription factors, such as NEUROD1, BRN3A, and ISL1, specifically within nociceptive neurons, while repressing non-nociceptor cell fates. Essential for the proper function of nociceptors in adults, influencing both their excitability and their gene expression, thereby impacting how these neurons respond to various pain stimuli.

配列の類似性

Belongs to the class V-like SAM-binding methyltransferase superfamily.

細胞内局在性

Nucleus

style

left-column

製品プロトコール

Visit the General protocols
Visit the Troubleshooting

style

left-column

ターゲットの情報

See full target information PRDM12

style

left-column

style

left-column

style

right-column

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Recombinant Human PRDM12 protein (GST tag N-Terminus)