JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB101091

Recombinant Human PITPNB protein (His tag N-Terminus)

Recombinant Human PITPNB protein (His tag N-Terminus)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human PITPNB protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 271 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

別名を表示する

Phosphatidylinositol transfer protein beta isoform, PI-TP-beta, PtdIns transfer protein beta, PtdInsTP beta, PITPNB

1 Images
SDS-PAGE - Recombinant Human PITPNB protein (His tag N-Terminus) (AB101091)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human PITPNB protein (His tag N-Terminus) (AB101091)

15% SDS-PAGE analysis of ab101091 (3μg)

Key facts

精製度

>95% SDS-PAGE

ab101091 was purified using conventional chromatography techniques.

発現系

Escherichia coli

タグ

His tag N-Terminus

アプリケーション

Mass Spec, SDS-PAGE

applications

生物活性

No

アクセッション番号

P48739

アニマルフリー

No

キャリアフリー

No

種

Human

バッファー組成

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

style
left-column

組合せ製品

Reagents, Controls & Accessories

AB325997

Prestained Protein Ladder - Extra broad molecular weight (3-250 kDa, 5-color)

SDS-PAGE - Prestained Protein Ladder - Extra broad molecular weight (3-250 kDa, 5-color) (AB325997)

  • 0
  • 0
Proteins & Peptides

AB101666

Recombinant Human PITPN protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human PITPN protein (His tag N-Terminus) (AB101666)

  • 0
  • 0
Primary Antibodies

AB127563

Anti-PITPNB antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PITPNB antibody (AB127563)

  • 0
  • 0
Proteins & Peptides

AB99139

Recombinant Human NTF2 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human NTF2 protein (His tag N-Terminus) (AB99139)

  • 0
  • 0
Proteins & Peptides

AB158453

Recombinant Human Filamin C protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human Filamin C protein (GST tag N-Terminus) (AB158453)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

配列情報

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMVLIKEFRVVLPCSVQEYQVGQLYSVAEASKNETGGGEGIEVLKNEPYEKDGEKGQYTHKIYHLKSKVPAFVRMIAPEGSLVFHEKAWNAYPYCRTIVTNEYMKDDFFIKIETWHKPDLGTLENVHGLDPNTWKTVEIVHIDIADRSQVEPADYKADEDPALFQSVKTKRGPLGPNWKKELANSPDCPQMCAYKLVTIKFKWWGLQSKVENFIQKQEKRIFTNFHRQLFCWIDKWIDLTMEDIRRMEDETQKELETMRKRGSVRGTSAADV","proteinLength":"Full Length","predictedMolecularWeight":"33.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":271,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P48739","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
style
left-column

出荷温度及び保存条件

製品の状態
Liquid
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
False
style
left-column

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

PITPNB also known as phosphatidylinositol transfer protein beta isoform plays a role mechanically in lipid transfer between membranes. It weighs around 32 kDa. You can find this protein expressed in various tissues including the brain liver and lungs. PITPNB facilitates lipid metabolism and signaling by transferring phosphatidylinositol and phosphatidylcholine between membranes.
Biological function summary

PITPNB ensures the proper distribution of lipids within cells for membrane composition and signaling activities. It participates in maintaining the balance of lipid composition among cell membranes. PITPNB does not function alone; it often acts as part of lipid transfer complexes collaborating with other proteins to execute its function properly.

Pathways

PITPNB plays an active role in phosphoinositide signaling and membrane trafficking pathways. These pathways are critical for cell signaling and membrane dynamics. PI4K2A and PI4KA are proteins related to these pathways and interact with PITPNB highlighting its contribution to complex intracellular signaling processes.

Defects in PITPNB have been linked to metabolic disorders and neurodegenerative diseases such as Alzheimer's. PITPNB is connected to APOE a protein involved in lipid metabolism and associated with Alzheimer's disease progression. Understanding the role of PITPNB in these conditions opens possibilities for therapeutic strategies targeting lipid transfer processes.
style
left-column

一般的な情報

機能

Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (PubMed : 10531358, PubMed : 18636990, PubMed : 20332109). Also catalyzes the transfer of sphingomyelin (By similarity). Required for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum; phosphatidylinositol and phosphatidylcholine transfer activity is essential for this function (PubMed : 20332109).

配列の類似性

Belongs to the PtdIns transfer protein family. PI transfer class I subfamily.

翻訳後修飾

Constitutive phosphorylation of Ser-262 has no effect on phospholipid transfer activity but is required for Golgi targeting.

style
left-column

製品プロトコール

style
left-column

ターゲットの情報

Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (PubMed : 10531358, PubMed : 18636990, PubMed : 20332109). Also catalyzes the transfer of sphingomyelin (By similarity). Required for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum; phosphatidylinositol and phosphatidylcholine transfer activity is essential for this function (PubMed : 20332109).
See full target information PITPNB
style
left-column
style
left-column
style
right-column

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com