JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB219243

Recombinant Human Pepsinogen II/PGC protein (His tag C-Terminus)

Recombinant Human Pepsinogen II/PGC protein (His tag C-Terminus)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human Pepsinogen II/PGC protein (His tag C-Terminus) is a Human Full Length protein, in the 17 to 388 aa range, expressed in Baculovirus infected insect cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

別名を表示する

Gastricsin, Pepsinogen C, PGC

1 Images
SDS-PAGE - Recombinant Human Pepsinogen II/PGC protein (His tag C-Terminus) (AB219243)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human Pepsinogen II/PGC protein (His tag C-Terminus) (AB219243)

15% SDS-PAGE analysis of ab219243 (3μg).

Key facts

精製度

>95% SDS-PAGE

エンドトキシンレベル

< 1 EU/µg

発現系

Baculovirus infected insect cells

タグ

His tag C-Terminus

アプリケーション

SDS-PAGE

applications

生物活性

No

アクセッション番号

P20142

アニマルフリー

No

キャリアフリー

No

種

Human

バッファー組成

pH: 7.4 Constituents: PBS, 10% Glycerol (glycerin, glycerine)

storage-buffer

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column

製品の詳細

This product was previously labelled as Pepsinogen II
style
left-column

配列情報

[{"sequence":"AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMAYMDAAYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSRFNPSESSTYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEATTAMQGMVQEGALTSPVFSVYLSNQQGSSGGAVVFGGVDSSLYTGQIYWAPVTQELYWQIGIEEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMSALLQATGAQEDEYGQFLVNCNSIQNLSLTFIINGVEFPLPPSSYILSNNGYCTVGVEPTYLSSQNGQPLWILGDVFLRSYYSVYDLGNNRVGFATAALEHHHHHH","proteinLength":"Full Length","predictedMolecularWeight":"42 kDa","actualMolecularWeight":null,"aminoAcidEnd":388,"aminoAcidStart":17,"nature":"Recombinant","expressionSystem":"Baculovirus infected insect cells","accessionNumber":"P20142","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
style
left-column

出荷温度及び保存条件

出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
保管に関する情報
Avoid freeze / thaw cycle
False
style
left-column

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Pepsinogen II also known as PGC or progastricsin functions as a digestive zymogen activated to pepsin in the acidic environment of the stomach. This enzyme precursor has a molecular mass of approximately 42-47 kDa. It is primarily expressed in the gastric chief cells and mucous cells of the stomach lining. Pepsinogen II plays an important role in the initial digestion of proteins breaking down complex protein molecules into peptides.
Biological function summary

Pepsinogen II contributes to digestive processes by converting into active pepsin at low pH levels facilitating protein degradation. Unlike some other digestive enzymes pepsin works independently from a complex. The production and secretion of pepsinogen II align with the gastric acid production ensuring efficient digestive activity. Its expression is vital for proper nutritional absorption and maintenance of gastrointestinal health.

Pathways

Pepsinogen II is closely involved in the proteolytic enzyme pathway. It connects with other gastric enzymes such as pepsin A through the activation processes influenced by gastric acid secretion. This interplay among digestive enzymes ensures optimal protein breakdown and nutrient absorption. The regulatory mechanisms that modulate gastric acid and pepsinogen secretion play an integral role in maintaining the digestive efficiency.

Pepsinogen II levels can serve as biomarkers for certain gastric conditions including gastritis and gastric cancer. Altered levels of pepsinogen II are associated with atrophic gastritis where reduced enzyme levels reflect damage to gastric mucosa. Also increased serum pepsinogen II concentration can indicate potential gastric cancer risk. These conditions highlight pepsinogen II's clinical importance in gastrointestinal disease diagnosis and management.
style
left-column

製品の性状

製品の状態

Liquid

補足情報

Affinity purified

style
left-column

一般的な情報

機能

Hydrolyzes a variety of proteins.

配列の類似性

Belongs to the peptidase A1 family.

style
left-column

製品プロトコール

style
left-column

ターゲットの情報

Hydrolyzes a variety of proteins.
See full target information PGC
style
left-column
style
left-column
style
right-column

組合せ製品

Proteins & Peptides

AB159101

Recombinant Human Pepsin protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human Pepsin protein (AB159101)

  • 0
  • 0
Primary Antibodies

AB255826

Anti-Pepsinogen II/PGC antibody [EPR22843-269]

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Pepsinogen II/PGC antibody [EPR22843-269] (AB255826)

  • 0
  • 0
Primary Antibodies

AB50123

Anti-Pepsinogen I antibody [7G3]

BOND RX™ Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Pepsinogen I antibody [7G3] (AB50123)

  • 4
  • 3
Assay Kits

AB275552

Human PGC ELISA Kit

Recombinant|SimpleStep

Sandwich ELISA - Human PGC ELISA Kit (AB275552)

  • 0
  • 0

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com