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Recombinant Human p53 BP3 protein (Tagged) (ab160881)

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SDS-PAGE - Recombinant Human p53 BP3 protein (ab160881)

    Key features and details

    • Expression system: Wheat germ
    • Tags: GST tag N-Terminus
    • Suitable for: ELISA, WB

    製品の詳細

    • 製品名

      Recombinant Human p53 BP3 protein (Tagged)

    • 発現系

      Wheat germ

    • アクセッション番号

      Q9NS56

    • タンパク質長

      Protein fragment

    • Animal free

      No

    • 由来

      Recombinant

      • 生物種

        Human

      • 配列

        SPDSKCPICLDRFDNVSYLDRCLHKFCFRCVQEWSKNKAECPLCKQPFDS IFHSVRAEDDFKEYVLRPSYNGSFVTPDRRFRYRTTLTRERNASVYSPSG PVNRRTTT

      • 予測される分子量

        38 kDa including tags

      • 領域

        98 to 205

      • タグ

        GST tag N-Terminus

      • 配列の追加情報

        NP_005793

    特性

    Our Abpromise guarantee covers the use of ab160881 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • アプリケーション

      ELISA

      Western blot

    • 製品の状態

      Liquid

    • 備考

       

       

    • Concentration information loading...

    前処理および保存

    • 保存方法および安定性

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      pH: 8.00
      Constituents: 0.31% Glutathione, 0.79% Tris HCl

    関連情報

    • 別名

      • AW105885
      • E3 ubiquitin protein ligase Topors
      • E3 ubiquitin-protein ligase Topors
      • LUN
      • p53 binding protein 3
      • p53 BP3/LUN
      • p53-binding protein 3
      • p53BP3
      • p53BP3/LUN
      • Retinitis pigmentosa 31
      • RP31
      • SUMO1 protein E3 ligase Topors
      • SUMO1-protein E3 ligase Topors
      • Topoisomerase I binding arginine/serine rich
      • Topoisomerase I binding arginine/serine rich protein
      • Topoisomerase I binding protein
      • Topoisomerase I binding RING finger protein
      • Topoisomerase I-binding arginine/serine-rich protein
      • Topoisomerase I-binding RING finger protein
      • Topoisomerase I-binding RS protein
      • Topors
      • TOPRS_HUMAN
      • TP53BPL
      • Tumor protein p53 binding protein
      • Tumor suppressor p53 binding protein 3
      • Tumor suppressor p53-binding protein 3
      see all

    • 機能

      Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation.

    • 組織特異性

      Expressed at highest levels in testis and at lower levels in adrenal gland, bone marrow, brain, colon, heart, kidney, liver, muscle, ovary, pancreas, placenta, prostate, skeletal muscle, skin, small intestine, spleen, stomach, testis, thymus, thyroid and uterus. Expressed in the alveolar epithelium of the lung. Expression is commonly decreased in colon adenocarcinomas and lung cancers.

    • 関連疾患

      Defects in TOPORS are the cause of retinitis pigmentosa type 31 (RP31) [MIM:609923]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP31 inheritance is autosomal dominant.

    • 配列類似性

      Contains 1 RING-type zinc finger.

    • 翻訳後修飾

      Phosphorylation at Ser-98 regulates the E3 ubiquitin-protein ligase activity but not the SUMO1-protein ligase activity. Phosphorylation at Ser-718 increases the E3 ubiquitin-protein ligase activity versus the SUMO1-protein ligase activity resulting in increased p53/TP53 ubiquitination and degradation.
      Sumoylated.

    • 細胞内局在

      Nucleus. Nucleus > PML body. Localizes to discrete nuclear foci which partly overlap with PML nuclear bodies. Targeted to PML nuclear bodies upon DNA damage.
    • Information by UniProt

    画像

    • SDS-PAGE - Recombinant Human p53 BP3 protein (ab160881)
      SDS-PAGE - Recombinant Human p53 BP3 protein (ab160881)

      12.5% SDS-PAGE analysis of ab160881, stained with Coomassie Blue.

    プロトコール

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    参考文献 (0)

    ab160881 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab160881 は論文での使用が確認できていません。

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