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Recombinant Human p38 gamma/MAPK12 protein (ab45160)

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SDS-PAGE - Recombinant Human p38 gamma/MAPK12 protein (ab45160)

    Key features and details

    • Expression system: Baculovirus infected Sf9 cells
    • Purity: > 90% SDS-PAGE

    製品の詳細

    特性

    Our Abpromise guarantee covers the use of ab45160 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • 製品の状態

      Liquid

    • 備考

      Recombinant full-length human MAPK 12 was expressed by baculovirus in Sf9 insect cells.

    • Concentration information loading...

    前処理および保存

    • 保存方法および安定性

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      pH: 7.50
      Constituents: 0.0418% EGTA, 0.00174% PMSF, 0.385% DTT, 0.79% Tris HCl, 0.00292% EDTA, 25% Glycerol (glycerin, glycerine), 0.87% Sodium chloride

    関連情報

    • 別名

      • ERK 6
      • ERK-6
      • ERK6
      • Extracellular signal-regulated kinase 6
      • MAP kinase 12
      • MAP kinase p38 gamma
      • MAPK 12
      • Mapk12
      • Mitogen Activated Protein Kinase 12
      • Mitogen activated protein kinase p38 gamma
      • Mitogen-activated protein kinase 12
      • Mitogen-activated protein kinase p38 gamma
      • MK12_HUMAN
      • P38 GAMMA
      • P38GAMMA
      • PRKM12
      • SAPK 3
      • SAPK-3
      • SAPK3
      • Stress Activated Protein Kinase 3
      • Stress-activated protein kinase 3
      see all

    • 機能

      Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation.

    • 組織特異性

      Highly expressed in skeletal muscle and heart.

    • 配列類似性

      Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
      Contains 1 protein kinase domain.

    • ドメイン

      The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

    • 翻訳後修飾

      Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme.

    • 細胞内局在

      Cytoplasm. Mitochondrion. Mitochondrial when associated with SH3BP5.
    • Information by UniProt

    画像

    • SDS-PAGE - Recombinant Human p38 gamma/MAPK12 protein (ab45160)
      SDS-PAGE - Recombinant Human p38 gamma/MAPK12 protein (ab45160)

    プロトコール

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    参考文献 (0)

    ab45160 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab45160 は論文での使用が確認できていません。

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